鹿角方改善充血性心力衰竭患者心脏功能的量化评估(英文)  

Quantitative evaluation on the effect of Lujiao prescription on cardiac function of patients with congestive heart failure

作　　者：蔡辉[1] 胡婉英[2] 王艳君[3] 张俊慧[1] 郭郡浩[1] 胡兵[1] 

机构地区：[1]解放军南京军区南京总医院中西医结合科,江苏省南京市210002 [2]上海中医药大学附属曙光医院,上海200021 [3]河北医科大学博士后流动站,河北省石家庄市050017

出　　处：《中国临床康复》2006年第27期152-155,共4页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:充血性心力衰竭是各种心脏病的严重或终末阶段的一种临床综合征,约半数以上的器质性心脏病患者在其晚期都将发生心力衰竭。心力衰竭不仅发病率高,其死亡率也极高,五年存活率远不及恶性肿瘤。目的:观察鹿角方治疗充血性心力衰竭的临床疗效并分析其作用机制。设计:以充血性心力衰竭患者为研究对象的对比观察,前后对照试验。单位:上海中医药大学附属曙光医院心血管内科。对象:实验于1996-01/1998-12在上海中医药大学附属曙光医院心血管内科完成。选择心血管病房及专科门诊的充血性心力衰竭患者60例,男31例,女29例。纳入标准:①临床症状符合Framinham心力衰竭诊断标准。②纽约心脏病学会心功能Ⅲ级以上。③病史3个月以上。④接受适量的利尿剂或扩血管药物(血管紧张素转换酶抑制剂除外)作基础治疗。⑤胸部X片及超声心动图有左室扩大的证据。⑥中医辨证按中国中西医结合研究会1986年中医虚证辨证参考标准。两组充血性心力衰竭患者基础疾患及一般情况差异无显著性。方法:将60例充血性心力衰竭患者随机抽签法按2:1比例分为鹿角方组40例、地高辛组20例,给予鹿角方组患者口服鹿角方口服液35mL(每毫升含生药1.6g),2次/日,4周为1疗程。地高辛组患者口服地高辛片0.125-0.25mg,1次/日,4周为1疗程。于4周后观察两组患者临床疗效、肾虚症状积分、纽约心脏病学会心功能分级、Lee心衰评分、心率、心肌耗氧量、心胸比例、超声心动图(射血分数、心输出量、舒张期室间隔厚度、舒张期左室后壁厚度、左室重量指数)、放射免疫法测定血浆心钠素、血管紧张素Ⅱ水平等指标。主要观察指标:①临床疗效。②肾虚症状积分。③纽约心脏病学会心功能分级。④Lee心衰评分。⑤心率、心肌耗氧量。⑥心胸比例。⑦超声心动图检查。⑧血浆心钠素�BACKGROUND： Congestive heart failure （CHF） is the clinical syndrome of all kinds of heart disease on the serious or final stage. About half of patients with organic heart disease will have heart failure that has a high incidence rate and mortality. The survival of heart failure was inferior to that of malignant tumor. OBJECTIVE： To confirm the clinical effect of Lujiao preseription on CHF and elucidate its possible mechanism. DESIGN： A control observation on CHF patients. SETTING： Department of Cardiovasology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. PARTICIPANTS： A total of 60 patients with CHF were selected from the department of eardiovasology in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 1996 to December 1998. There were 31 male and 29 female. Included criteria： ①All of patients were consistent with Framinham diagnostic criteria. ② Above Ⅲ dery gree by New York Heart Association（NYHA）. ③ Three months ease history. ④Aecept quantity sufficient diuretic and vasodilating agent （exclude angiotensin converting enzyme inhibitor ）. ⑤ Left ventricle hypertrophy was proved by eehocardiogram or chest X-ray. ⑥ Differentiation of symptoms and signs of Traditional Chinese Medicine refers to asthenia syndrome of differentiation of symptoms and signs of Traditional Chinese Medicine （1986, Researching Association of Chinese integrated medicine） General state of health and basic disease of the patients in the two groups were not significant deviation. METHODS： 60 patients of CHF were randomly divided into Lujiao prescription group（n=40） and Digoxin group （n=20） at the rate of 2：1. Lujiao prescription group： Orally liquid decoction of Lujiao Prescription 35 mL （1 mL contain crude drug 1.6 g） Bid. po. Course of treatment： 4 weeks. Digoxin group： Digoxin tablet, 0.125-0.25 mg, qd. po. course of treatment： 4 weeks. After 4-week treatment, the patients＇ clini

关 键 词：充血性心力衰竭 左室肥厚 鹿角方 

分 类 号：R541.6[医药卫生—心血管疾病]