加替沙星滴眼液家兔药效学试验及临床观察  

Pharmacodynamic and Clinical Study of Gatifloxacin Eye Drops in Rabbit

作　　者：刘莹珍[1] 陈光龙[1] 廖朝峰[1] 

机构地区：[1]广东省深圳市宝安人民医院药剂科,广东深圳518101

出　　处：《中国药业》2006年第11期31-32,共2页China Pharmaceuticals

摘　　要：目的评价加替沙星滴眼液的药效学与临床疗效。方法以氧氟沙星滴眼液为对照,用35只家兔作眼部刺激性和药效学试验,并观察其对25例细菌混合感染性结膜炎、角膜炎患者的临床疗效,给药方法为5次/d,1～2滴/次,疗程7～14d。结果家兔细菌清除率试验组与对照组分别为89.70%和87.88%;临床观察试验组与对照组临床有效率分别为88.00%和84.00%,细菌清除率分别为87.10%和86.67%,均无显著性差异(P>0.05),未见刺激性反应和其他不良反应。结论加替沙星滴眼液对中重度细菌性感染安全、有效。Objective To investigate the pharmacodynamics and efficacy of gatifloxacin eye drops（GED）. Methods To compare the ofloxacin eye drops （OED） and GED, the stimulation and pharmacopsychosis test with 35 rabbits eye and clinical efficacy treated for 25 patients （conjunctivitis and comeitis） with moderate - to - severe bacterial infections. The doses 0. 1 mL divided every 5 h for 7 - 14 d. Efficacy evaluations included bacterial eradication rates and clinical response. Results The bacterial eradication rates were 89.70% for GED and 87.88% for OED respectively in rabbit eye with moderat- to- severe bacteriat infections. Of 50 treated patients, 25 received GED and 25 received OED. The overall efficacy rates （i. e. cure or markedly improved） were 88.00% for GED and 84.00% for OED. The bacterial eradication rates were 87. 10% for GED and 86.67% for OED （ P 〉 0.05）, respectively. Both drug regimens were well tolerated, the stimulation and adverse events were few and mild. Conclusion GED is safe and effective for the treatment of moderate- to- severe bacterial infections.

关 键 词：加替沙星滴眼液 药效学 临床观察 

分 类 号：R965[医药卫生—药理学] R988.1[医药卫生—药学]