枳椇子对酒后血中乙醇质量浓度和肝中乙醇脱氢酶活性的影响  

Influence of Hovenia dulcis on alcohol concentration in blood and activity of alcohol dehydrogenase(ADH) of animals after drinking

作　　者：陈绍红[1] 钟赣生[1] 李爱里[1] 李少华[1] 吴立坤[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国中药杂志》2006年第13期1094-1096,共3页China Journal of Chinese Materia Medica

摘　　要：目的：探讨枳棋子对急性乙醇中毒的防治作用。方法：雄性小鼠随机分为空白组、模型组、枳棋子提取物组，给药30min后，模型组与枳棋子组灌酒0．015mL·g^-1，在灌酒后0．5，1，1．5，2，2．5，3h分别摘眼球取血和取肝组织。采用生化酶法，测定小鼠酒后不同时间内血中乙醇浓度和肝中乙醇脱氢酶（ADH）活性。结果：小鼠血中乙醇浓度在酒后0．5～1．5h达到高峰，与模型组相比，枳棋子提取物组0．5～3h内的血中乙醇浓度数值降低。枳棋子提取物组对小鼠酒后1～1．5h肝中ADH的影响较为明显，使其活性增加；酒后2～3h肝中ADH活性虽然也增强，但与模型组比较无显著差异。结论：枳棋子提取物可降低酒后血中乙醇浓度，增强肝中ADH活性，其机制可能是通过抑制消化道对乙醇的吸收，从而起到有效的降醇解酒作用。Objective： To observe the effects of H. dulcis on relieving alcohol toxicity by animalexperiments. Method： Male kunruing mice were ovmiectomized and randomly divided into 5 groups： control group, model group, and aqueous extracts of H. dulcis group at 0.5, 0.25, 0.125 g·mL^-1. The acute alcoblism animals induced by gastral administration with ＂Er Guo Ton＂ and the alchol concentrations in serum were detected after treated with the extracts within 0.5-3 h by biochemical enzymes. Result： The alcohol concentration in blood was up to the maximum in 0.5-1.5 h. However, the alcohol concentratioons in blood of aqueous extract from H. dulcis group were decreased in 0.5- 3 h. The activity of ADH in the fiver in aqueous extract of H. dulcis group was increased in 2-3 h, while it was significantly increased in 1- 1.5 h（ P 〈0.05）. Conclusion： The aqueous extract of H. dulcis could reduce the alehol concentration in blood of animals and inrease the activity of ADH after given alcohol. It meaus the extract has the effect of relieving alcohol toxicity and preventing drunkenness through restraining the absorption of alcohol in the gastrointestinal tract and promoting the metabolism of alcohol in the fiver.

关 键 词：枳棋子 乙醇中毒 解酒 乙醇浓度 乙醇脱氢酶 

分 类 号：R285.5[医药卫生—中药学]