肝病患者血浆GMP-140检测及临床意义  

The clinic significance of detecting blood plasma GMP-140 in liverish patients

作　　者：杨清[1] 白杨[1] 霍德胜[2] 柳忠辉[2] 

机构地区：[1]吉林大学第一医院,吉林长春130021 [2]吉林大学基础医学院,吉林长春130021

出　　处：《吉林医学》2006年第7期737-737,共1页Jilin Medical Journal

摘　　要：目的:探讨血小板α-颗粒膜蛋白(GMP-140)在肝病诊断中的意义。方法:采用酶联免疫吸附实验(ELISA)检测肝病患者血浆GMP-140含量。结果:3组肝病患者GMP-140含量与正常对照组比较均显著升高(P<0.01)。丙型、乙型肝炎相比无明显差异(P>0.05)。肝癌患者血浆GMP-140较丙型、乙型肝炎显著增高(P<0.05;P<0.01)。结论:检测肝病患者GMP-140可做为肝病患者,尤其是肝癌患者纤溶亢进及评估预后的指标。Objective To discuss the diagnosis significance of blood platelet a-granule membrane protein （GMP-140）in liver disease. Method The content of blood plasma GMP-14 in liverish patients were detected by enzyme linked immunosorbent assay （ELISA）. Results The content of GMP-140 in three group liverish patients were significantly higher than those in controls （P〈 0.01）.The content were not significantly different between hepatitis B virus and hepatitis C virus patients. The content of GMP-140 were significantly higher in liver cancer patients than those in hepatitis B virus and hepatitis C virus patients （P〈0.05;P〈0.01）. Conclusion Detecting the content of liverish patients GMP-140 can be a guideline of sthenic fibrinolysis in liverish patients especially liver cancer patients and to evaluate the prognosis.

关 键 词：肝病患者 血小板Α-颗粒膜蛋白 

分 类 号：R446.6[医药卫生—诊断学]