居留南极对考察队员血浆色氨酸及尿中5－羟吲哚乙酸水平的影响  

EFFECTS OF RESIDING IN ANTARCTICA ON PLASMA TRYPTOPHAN AND URINARY 5 HYDROXY 3 INDOLEACETIC ACID IN EXPEDITION MEMBERS

作　　者：许澍淮[1,2] 金淑敏[1,2] 斯琴[1,2] 薛祚纮 王宗惠 薛全福[1,2] 

机构地区：[1]中国医学科学院基础医学研究所 [2]中国协和医科大学基础医学院 [3]北京大学 [4]北京市劳动卫生职业病防治研究所

出　　处：《南极研究》1996年第4期68-71,共4页

基　　金：国家"八五"攻关资助;国家自然科学资助

摘　　要：为探讨南极考察队员行为／性格变化的物质基础，观察了驻长城站考察队员血浆色氨酸（Ｔｒｐ）与尿中５－羟吲哚乙酸（５－ＨＩＡＡ）变化。第８次队及第１１次队两批队员变化规律相同，即血浆Ｔｒｐ降低，尿中排出５－ＨＩＡＡ增加，血浆Ｔｒｐ变化较尿排出５－ＨＩＡＡ变化出现早，恢复慢。本文讨论了血浆Ｔｒｐ。In order to study the possible relationship between the changes of behavior/personality and metabolic changes of 5 hydroxytryptamine(5 HT) in Antarctic expedition members,plasma tryptophan(Trp) and urinary 5 hydroxy 3 indoleacetic acid(5 HIAA) were studied in 24 winter over and 19 summer over members of the 8th and the 11th time teams respectively. Results showed that plasma Trp decreased significantly after 1￣3 months staying at Great Wall Station, and did not recover on returning back to Beijing from Antarctica after two weeks' travelling. Urinary 5 HIAA increased significantly after 6 months' staying at Great Wall Sation,and recovered after returning back to Beijing from Antarctica. The decrease of plasma Trp may relate to the decline of brain 5 HT, which might play a role in the changes of behavior/personality. The changes of urinary 5 HIAA might not only reflect metabolic changes of 5 HT , but also show that cold weather affects the releasing response of platelet. Therefore, supplement of related food rich in Trp or intervention of L Trp might be valuable.

关 键 词：南极 考察队员 血浆 色氨酸 尿液 五羟吲哚乙酸 

分 类 号：R446.112[医药卫生—诊断学] R188.13[医药卫生—临床医学]