异丙酚对脊髓损伤后大鼠血管反应性的影响  

Influence of propofol on spinal cord transected rat vascular reactivity

作　　者：石学银[1] 邹最[1] 夏建华[2] 徐振东[3] 吕砚[1] 何星颖[1] 刘刚[1] 

机构地区：[1]上海第二军医大学长征医院麻醉科,200003 [2]解放军第411医院麻醉科 [3]复旦大学附属华山医院麻醉科

出　　处：《解放军医学杂志》2006年第7期701-703,共3页Medical Journal of Chinese People's Liberation Army

基　　金：上海市科委基金资助课题(054119522);上海市卫生局基金资助课题(024097)

摘　　要：目的观察大鼠高位脊髓横切(SCT)慢性期腹主动脉对α-肾上腺素受体(α-AR)激动剂的反应及异丙酚对其的影响,探讨自主神经反射异常(AD)的血管机制及异丙酚对AD的抑制作用。方法64只Wistar大鼠随机分为对照组和SCT组,取SCT4周后大鼠腹主动脉,通过离体血管环张力测定技术,观察血管环对梯度浓度去甲肾上腺素(NE)、去氧肾上腺素(Phe)、可乐定以及异丙酚的敏感性。结果与对照组相比,高位SCT大鼠腹主动脉血管环对NE、可乐定的反应性升高(P<0·05或P<0·01),而对Phe的反应性没有明显改变。SCT后大鼠血管环对异丙酚的舒张作用更敏感(P<0·05或P<0·01)。结论对α2-AR激动剂敏感性上调可能是高位SCT大鼠腹主动脉高反应性的原因,而α1-AR在血管高反应性中不起作用。SCT大鼠血管对异丙酚的舒张作用更为敏感。Objective To observe the reactivity of spinal cord transection （SCT） rat abdominal aorta to α-AR agonists and the infuence of propofol on vascular reactivity, so as to explore the mechanism of autunomic dysreflxia. Methods The rats were divided into sham-operated group and SCT group. 4 weeks after transection of the fourth thoracic spinal cord, the rots were killed, then abdominal aorta rings were adopted to assay their sensitivity to noradrenaline, phenylephrine, clonidine and propofol in isolated organ perfusion system. Results Compared with the rots in sham-operated group, the abdominal aorta reactivity of SCT rats to noradrenaline and clonidine was significantly higher （P〈0. 05 or P〈0. 01）, but vascular reactivity to phenylephrine showed no significant change. Propofol performed a stronger effect on vascular relaxation in SCT rats than in sham-operated rots （P〈0. 05 or P〈0. 01）. Conclusion The accemuation of vascular sensitivity to α2-AR agonist may be one of the mechanisms of abdominal aorta hyperreactivity. The abdominal aorta in SCT rat is more sensitive to propofol than that of sham-operated rats.

关 键 词：脊髓损伤 自主神经反射异常 受体 肾上腺素能Α 血管反应性 异丙酚 

分 类 号：R614[医药卫生—麻醉学]