鼻息肉患者肺炎衣原体的检测  被引量:1

Detection of Chlamydia Pneumoniae in Patients with Nasal Polyps

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作  者:黄新妍[1] 徐林根[1] 徐坚[2] 余竹元[3] 

机构地区:[1]复旦大学附属金山医院耳鼻咽喉-头颈外科,上海200540 [2]复旦大学附属金山医院职防科,上海200540 [3]复旦大学附属中山医院内科免疫室,上海200032

出  处:《中国眼耳鼻喉科杂志》2006年第4期233-234,239,共3页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘  要:目的探索肺炎衣原体(chlamydia pneumoniae,Cpn)与鼻息肉之间的关系。方法用直接免疫荧光法检测外周血单核细胞(peripheral blood mononclear cell,PBMC)中的 Cpn 特异性抗原(Cpn-Ag),间接微量免疫荧光法检测血浆中 Cpn 抗体。结果在73例鼻息肉患者和87例正常人血浆中,Cpn IgG 的阳性检出率分别为65.8%(48/73)和32.2%(28/87),P<0.001;Cpn IgM 的阳性检出率分别为30.1%(22/73)和12.6%(11/87),P<0.01;PBMC 中的 Cpn-Ag 阳性检出率分别为86.3%(63/73)和31.0%(27/87),P<0.001。结论鼻息肉与肺炎衣原体有一定的相关性。检测 PBMC 中 Cpn-Ag 可为更好的治疗鼻息肉提供实验依据。Purpose To explore the relationship between Chlamydia pneumoniae(Cpn) and nasal polyps. Methods The peripheral blood mononuclear cell (PBMC) specific antigen (Ag) to Cpn was measured by direct Plasma specific antibodies to Cpn( IgG. IgM) were measured by microimmunofluorescence test. Results In plasma of 73 patients with nasal polyps and. 87 normal controls, Cpn IgG positive rate was 65.8% (48/73) and 32.2% (28/87) respectively, (P〈0.001). Cpn-IgM positive rate was 30.1%(22/73) and 12.6%(11/87) respectively, (P 〈 0.01). PBMC Cpn-Ag positive rote was 86.3% (63/73) and31.0% (27/87) respectively,(P 〈0.001).Conclusion There was certain correlation between nasal polyps and Cpn. Detection of PBMC Cpn-Ag has provided the experimental basis of better treatment for nasal polyps. (Chin J Ophthalmol and Otorhinolaryngology,2006,6:233 - 234)

关 键 词:鼻息肉 肺炎衣原体 微量免疫荧光 

分 类 号:R765.25[医药卫生—耳鼻咽喉科]

 

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