脑白质疏松的扩散张量成像(DTI)研究  

The DTI Study in the Cerebral White Matter of Leukoaraiosis

作　　者：张雪宁[1] 张云亭[1] 

机构地区：[1]天津医科大学总医院放射科,300052

出　　处：《临床放射学杂志》2006年第7期593-597,共5页Journal of Clinical Radiology

基　　金：国家重点基础研究发展计划(973计划)"重要临床医学信息处理的关键科学问题研究"(No.2003CB716100)

摘　　要：目的应用扩散张量成像(DTI)检查脑白质疏松(LA)病灶的平均扩散系数(DCavg)、各向异性(FA)值与LA严重程度的关系,探讨常规MRI检查正常的脑白质微结构在DTI中的变化及与认知功能的关系。资料与方法对55例LA患者和22名健康老年人行DTI检查,测量LA病灶和正常白质区域的DCavg、FA值。结果LA程度越严重,DCavg值越高,呈正相关;FA值越低,呈负相关。神经心理学测试(简易智能精神状态量表,MMSE)与LA患者的正常脑白质区域的DCavg、FA值明显相关,尤其是前角白质、半卵圆中心的正常脑白质。结论DTI检查LA,其DCavg、FA值显示出特征性的改变,DTI能够发现常规MRI检查正常的脑白质微结构改变,且这种改变与认知功能相关。Objective To find DCavg and FA values of ROI（regions of interest） correlating with the degree of the severity of leukoaraiosis （LA） by using DTI, and provides information about white matter microstructural changes and correlates with cognition dysfunction. Materials and Methods Diffusion tensor MR imaging was performed in 55 patients with LA （25 healthy subjects with LA and 30 ischamic LA） and 22 healthy aging without LA. DCavg and FA values were calculated for the regions of NLA （normal subjects with LA ）, ILA （ischamic LA） lesions and normal white matter areas. Results The more severe the LA was, the higher the DCavg values and the lower FA values of the leukoaraiotic regions were, which was negative correlation. The significant correlation was identified between normal appearing white matter of DTI and MMSE scores, especially in the white matter of anterior horn of ventricle and semi-oval. Conclusion The regions of LA are depicted characteristic changes in DCavg and FA values by DTI, DTI can find microstructural white matter changes which are normally seen with conventional MBI, and these changes correlate with cognition dysfunction.

关 键 词：磁共振成像 扩散张量成像 老年人 脑白质疏松 白质 

分 类 号：R445.2[医药卫生—影像医学与核医学]