Different Effects of Capsaicin on I_ A and I_ K in Pain-conduct Neurons of Rats  

作　　者：付晖 刘慧 曹雪红 胡燕 向继洲 刘烈炬 

机构地区：[1]Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2006年第3期275-277,共3页华中科技大学学报（医学英德文版）

基　　金：ThisprojectwassupportedbyagrantfromtheNationalNaturalSciencesFoundationofChina(No.30271500).

摘　　要：The different effects of capsaicin on IA and IK currents in pain-conduct neurons of trigeminal ganglia （TG） were investigated. In cultured TG neurons of rats, whole-cell patch clamp techniques were used to record the IA and IK before and after capsaicin perfused. Results revealed that 1 μmol/L capsaicin could inhibit the amplitude of IA by 48.2% （n= 10, P〈0.05）, but had no inhib- itory effect on IK （n=7, P〈0.05）. Ten μmol/L capsaicin could significantly inhibit the amplitude of IA by 93.2 % （n=8, P〈0.01）, but only slightly inhibit the amplitude of IK by 13.2 % （n=7, P〈0.05）. Neither 1 μmol/L nor 10 μmol/L capsaicin had effects on the active curve of IA and IK. It was concluded that capsaicin could selectively inhibit the IA current, and this effect might involve in the analgesic mechanisms of capsaicin.The different effects of capsaicin on IA and IK currents in pain-conduct neurons of trigeminal ganglia （TG） were investigated. In cultured TG neurons of rats, whole-cell patch clamp techniques were used to record the IA and IK before and after capsaicin perfused. Results revealed that 1 μmol/L capsaicin could inhibit the amplitude of IA by 48.2% （n= 10, P〈0.05）, but had no inhib- itory effect on IK （n=7, P〈0.05）. Ten μmol/L capsaicin could significantly inhibit the amplitude of IA by 93.2 % （n=8, P〈0.01）, but only slightly inhibit the amplitude of IK by 13.2 % （n=7, P〈0.05）. Neither 1 μmol/L nor 10 μmol/L capsaicin had effects on the active curve of IA and IK. It was concluded that capsaicin could selectively inhibit the IA current, and this effect might involve in the analgesic mechanisms of capsaicin.

关 键 词：eapsaicin pain-conduct neurons IA current IK current rat 

分 类 号：R285[医药卫生—中药学]