精子DNA损伤与保护  

Damage to and Protection of Sperm DNA

作　　者：孙洁[1] 周安方[1] 

机构地区：[1]湖北中医学院中医基础理论教研室,湖北武汉430061

出　　处：《中华男科学杂志》2006年第7期639-642,646,共5页National Journal of Andrology

基　　金：湖北省自然科学基金资助(2004ABA184)

摘　　要：精子DNA损伤是引起不育的重要原因,携有DNA损伤的幸存精子可能逃避体内精子选择机制而成熟并将遗传缺陷传递于后代。因此对精子DNA损伤的研究已成为生殖医学的热点之一。损伤精子DNA的因素主要包括氧化应激、微量元素、精子毒性物质、放射线等,而机体则凭借高度压缩精子DNA、抗氧化系统等机制保护精子DNA的完整性。此外,一些药物如抗氧化剂、黑茶提取物等也可以促使这种保护机制的健全与重建。The damage to sperm DNA is one of the most important causes of male infertility. Some sperm with damaged DNA may escape from the sperm surveillance mechanism and transmit the damage to the offspring. So research on the damage to sperm DNA has become one of the hot spots in reproductive medicine. The factors that would damage sperm DNA include oxidative stress, microelements, reproductive toxic substances, radioactive rays, and so on, while the body depends on the compressed sperm DNA and anti-oxidation system for the protection of the integrity of sperm DNA. Some drugs such as anti-oxidant, black tea extract, etc, may help to improve and rebuild these protective mechanisms.

关 键 词：精子 DNA 损伤 保护 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]