甘草酸脂质体的处方及制备工艺  

Formulation and preparation of glycyrrhizic acid liposome

作　　者：程建峰[1] 扈本荃[1] 刘梅[1] 贺建荣[1] 扬胜[1] 王弼时[1] 

机构地区：[1]第四军医大学唐都医院药学部,陕西西安710038

出　　处：《第四军医大学学报》2006年第7期655-657,共3页Journal of the Fourth Military Medical University

基　　金：陕西省中医管理局2003年招标课题(0389)

摘　　要：目的:优化甘草酸脂质体的处方及制备工艺.方法:用旋转蒸发薄膜超声法制备甘草酸脂质体,用均匀设计优选该脂质体的处方及制备工艺,采用扫描电镜观测其外观、大小及分布,用HPLC测定其包封率,初步考察该制剂的稳定性.结果:用旋转蒸发薄膜超声法制备的甘草酸脂质体球形圆整,大小较均匀,粒径40～60nm,包封率63.0%～89.0%.结论:薄膜分散法优化工艺后制备得到的脂质体包封率较高,稳定性较好.AIM： To optimize the prescription and preparation of encapsulated liposome. METHODS： The liposomes were prepared by conventional rotary-evaporated film-ultrasonication method. The prescription and preparation of liposome were optimized by uniform design. Its shape and size distribution were detected under transmission electron microscope. A method to determine the encapsulated rate of the liposome by high performance liquid （HPLC） was established. RESULTS： Glycyrrhizic acid liposome was regular under its microphotograph and the diameter was 40 - 60 nm. The entrapment efficiency of the glycyrrhizic acid liposome was 63.0% - 89.0%. CONCLUSION： The entrapment efficiency of glycyrrhizic acid liposome and the stability of glycyrrhizic acid liposome prepared by conventional rotary-evaporated film-ultrasonication method is good.

关 键 词：甘草酸 脂质体 均匀设计法 包封率 

分 类 号：R944.1[医药卫生—药剂学]