黄芪肠内营养对2型糖尿病合并缺血性卒中病人免疫功能影响  

Effect of Astragalus-supplemented enteral nutrition on immune function in type-2 diabetic patients with ischemic stroke

作　　者：王晓希[1] 李旻[2] 阎敏[3] 刘载道[1] 汤萍[1] 

机构地区：[1]中南大学湘雅医院营养科,湖南长沙410008 [2]中南大学湘雅医院神经内科,湖南长沙410008 [3]中南大学湘雅医院药剂科,湖南长沙410008

出　　处：《肠外与肠内营养》2006年第4期206-208,共3页Parenteral & Enteral Nutrition

摘　　要：目的:研究黄芪肠内营养对2型糖尿病合并缺血性卒中病人体液免疫(IgA、IgG、IgM)和细胞免疫(T细胞亚群)的影响。方法:将64例病人随机分为治疗组和对照组,每组32例。治疗组给予黄芪水煎液(相当于生药60 g)加改良匀浆膳;对照组给予能全力,共30 d。两组肠内营养支持前后均测定IgA、IgG、IgM和T细胞亚群,同时监测空腹血糖、血浆清蛋白、转铁蛋白和血红蛋白等营养指标。结果:①治疗组肠内营养支持后,IgG、IgM、CD4和CD4/CD8比值均升高,与对照组比较,差异有显著性意义(P<0.05,P<0.01);②治疗组肠内营养支持后空腹血糖降低,与对照组比较,差异有显著性意义(P<0.01)。③两组病人经营养支持后,转铁蛋白升高(P<0.05)。结论:黄芪肠内营养可明显改善2型糖尿病合并缺血性卒中病人免疫功能及空腹血糖。Objectives：To study the effect of Astragalus-supplemented enteral nutrition on the humoral immunity（IgA,IgG,IgM） , ceUular immunity （T-lymphocyte subsets） in type-2 diabetic patients with ischemic stroke. Methods ：64 cases of type-2 diabetic patients with ischemic stroke were randomly divided into treated group and control group. The treated group was treated with homogenized diet and Radix Astragalis（ equivalent to 60g crude drug）, and the control group was treated with Nutrison fibre. Venous blood from cubital vein was collected before and after treatment to detect the IgA,IgG,IgM, T-lymphocyte subsets,fasting blood glucose,serum proteins and the nutritional status was evaluated. Results： Compared with the control group, IgG ,IgM, CD4（ % ） ,CD4/CD8 ratio in the treated group increased significantly（ P 〈 0.05, P 〈 0.01 ） ;fasting blood glucose in the treated group was significantly improved （P 〈 0.01 ）. During the period of this study, the levels of serum proteins had no significant changes between two groups. Conclusions：Astragalus-supplemented enteral nutrition can improve the immune function and fasting blood glucose of type-2 diabetic patients with ischemic stroke.

关 键 词：2型糖尿病 缺血性卒中 黄芪 肠内营养 免疫功能 

分 类 号：R259[医药卫生—中西医结合] R459.3[医药卫生—中医内科学]