降压Ⅰ号对自发性高血压大鼠血压、血浆NO及ET的影响  

Effects of Jiangya Ⅰ on Blood Pressure,Serum Nitric Oxide (NO) and Endo the Lin(ET) in Spontaneous Hypertension Rats(SHR)

作　　者：陈颖[1] 黄永生[2] 

机构地区：[1]北京中医药大学,北京100029 [2]长春中医学院,吉林长春130021

出　　处：《中国中医基础医学杂志》2006年第5期364-365,共2页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:观察降压Ⅰ号对自发性高血压大鼠(SHR)血压、血浆一氧化氮(NO)及内皮素(ET)的影响。方法:50只SHR随机分成降压Ⅰ号组(高、中、低剂量)、空白组和阳性对照组,分别给予降压Ⅰ号(高、中、低剂量)、生理盐水及复方降压片,1个月后观察每组血压、NO及ET值。结果:各组血压、NO及ET值有显著差异(P<0.05),中药高剂量组明显优于其他4组。结论:降压Ⅰ号具有降低血压、ET和升高血浆NO的作用,其效果优于复方降压片。Objective：To observe the effects of Jiangya Ⅰ on the blood pressure, serum nitric oxide（NO） and endothelin （ET） in spontaneous hypertension rats（SHR）. Methods： Fifty SHR were randomly divided into the large, middle and small dose of jiangya Ⅰ treated group, blank group and compound reserpine tablets group.The groups treated by the large, middle and small dose of jiangya Ⅰ , normal saline and compound reserpine tablets respectively. After the end of one month, the blood pressure were measured, NO and ET of plasma were determinded respectively. Results：There were significant differences in blood pressure, NO and ET amongthe five groups（P 〈 0.01）.The large dose of Jiangya Ⅰ was superior to the other four groups. Conclusion： Jiangya Ⅰ can decrease BP, ET and increase NO. The effects of The large dose of jiangya Ⅰ is superior to compound reserpine tablets.

关 键 词：降压Ⅰ号 高血压 一氧化氮 内皮素 

分 类 号：R285.5[医药卫生—中药学]