上海地区健康老人血清氨基端前B型钠尿肽水平  

The serum level of N-terminal pro-B type natriuretic peptide in healthy old people in Shanghai area

作　　者：张佳明[1] 俞欢[1] 黄志坚[2] 李勇[3] 

机构地区：[1]复旦大学附属华山医院老年科,上海200040 [2]复旦大学附属华山医院检验科,上海200040 [3]复旦大学附属华山医院心内科,上海200040

出　　处：《检验医学》2006年第4期333-336,共4页Laboratory Medicine

基　　金：2004年上海市自然科学基金(04ZR14046)

摘　　要：目的了解上海老年健康人群的氨基端前B型钠尿肽(NT-proBNP)水平,和非老年人群及其他国家地区的老年人群作比较。方法用电化学发光免疫法体外定量检测98名健康老人血清中的NT-proBNP,分析其与年龄、性别等因素的关系。结果98名健康老人NT-proBNP(中位值)为53.25 ng/L。多元回归分析结果显示,左心室射血分数、血肌酐与NT-proBNP的关系较密切。结论60岁以上老人建议界值定为120 ng/L。Objective To investigate the level of N-terminal pro-B type natriuretic peptide （NT-proBNP） in healthy old people in Shanghai. Methods The levels of serum NT-proBNP in 98 old people were determined by electrochemiluminescent immunoassay （Elecsys 2010, Roche Diagnostics）. Results The median （range） concentrations of NT-proBNP in healthy old people were 53.25 （ 10.3 - 132.6 ） ng/L. Multi-factors linear regression analysis showed that left ventricular ejection fraction and serum creatinine might correlate to NT-proBNP. Conclusions The authors suggested the normal cut-off values of NT-proBNP for Shanghai healthy old people（≥ 60 years） might be 120 ng/L.

关 键 词：氨基端前B型钠尿肽 健康老人 电化学发光免疫分析 

分 类 号：R446.1[医药卫生—诊断学]