小儿花剥苔形成的相关因素及其免疫学机制  

Correlative Factors of Child Lingua Geographica Formation and the Immunological Mechanism

作　　者：李福凤[1] 庄燕鸿[1] 王忆勤[1] 李果刚[1] 燕海霞[1] 王惠芳[1] 

机构地区：[1]上海中医药大学教学实验中心综合实验教研室,上海市蔡伦路1200号201203

出　　处：《中医杂志》2006年第7期531-534,共4页Journal of Traditional Chinese Medicine

基　　金：上海市教委科研资助项目(03CK09);上海中医药大学校级基金资助项目(X066)

摘　　要：目的:探讨小儿花剥苔发生的主要相关因素及其免疫学机制。方法:运用临床流行病学方法调查1562例儿童,同时采用流式细胞术检测T、B淋巴细胞亚群、细胞趋化因子受体-3(CCR3)、细胞趋化因子受体-5(CCR5)表达量等。结果:花剥苔形成的主要因素为过敏、哮喘史、感染、先天体质等。花剥苔组T、B淋巴细胞亚群及CCR3、白细胞介素4水平高于非花剥苔组及正常组(P<0.05)。结论:小儿花剥苔形成与过敏、感染、哮喘史、先天体质密切相关,且T、B淋巴细胞亚群改变为花剥苔形成的免疫学机制提供了客观依据。Objective：To approach to main correlative factors of child lingua geographica formation and the immunological mechanism. Methods：l 562 children were surveyed with clinical epidemiological method,and flow cytometry was used to determin T- and Blymphocyte subgroups and expression of cell chemotactic factor receptor-3（CCR3） and cell chemotoctic factor receptor-5（CCR5）. Results ：The main correlative factors of child lingua geographica formation were anaphylaxis,asthma history ,infection ,congenital constitution. The levels of T- and B-lymphocyte subgroups,CCR3 and interlukin-4 in the lingua geographica group were higher than that in the non-lingua geographica group and the control group （P〈 0. 05）. Conclusion.. Formation of child lingua geographica is closely related with anaphylaxis,asthma history,infection and congenital constitution,and the changes of T- and B- lymphocyte subgroups provide an objective basis for immunological mechanisms of child lingua geographica formation.

关 键 词：舌诊 淋巴细胞亚群/代谢 @花剥苔 

分 类 号：R272[医药卫生—中医儿科学]