SM22α在细胞骨架组构及血管重塑中的作用  

The Role of SM22α in Cytoskeleton Organization and Vascular Remodeling

作　　者：史建红[1] 温进坤[1] 韩梅[1] 

机构地区：[1]河北医科大学基础医学研究所河北省医学生物技术实验室,石家庄050017

出　　处：《生理科学进展》2006年第3期211-215,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金资助课题(30570661)

摘　　要：血管平滑肌细胞(VSMC)表型转化是动脉粥样硬化、高血压和血管成形术后再狭窄等血管重塑性疾病的共同病理生理过程。VSMC表型转化过程中平滑肌特异基因的表达变化和细胞骨架的组构是当前研究的热点问题之一。平滑肌22α(SM22α)是近年发现的一种VSMC分化标志物,其表达具有平滑肌组织特异性和细胞表型特异性,该蛋白作为一种肌动蛋白细胞骨架相关蛋白参与VSMC骨架组构和收缩调节。本文就SM22α的结构特征及其在VSMC骨架组构和血管重塑中的作用机制进行综述。Phenotypic modulation of vascular smooth muscle cells （VSMCs） plays a key role in vascular remodeling diseases, such as atherosclerosis, hypertension and restenosis. Recent researches have focused on the expression regulation of VSMC-specific marker genes and cytoskeleton organization in association with phenotypic modulation of VSMCs. Smooth muscle 22 alpha （SM22α） is a novel differentiated VSMC marker, which is characterized by its smooth muscle tissue-specific and VSMC phenotype-specific expression pattern, and serves as an actin-association protein to participate in VSMC cytoskeleton organization and vascular remodeling. This article reviews recent advances in the characterization of SM22α structure and its mechanism in VSMC cytoskeleton organization and vascular remodeling.

关 键 词：SM22α 细胞骨架 血管重塑 平滑肌细胞表型 

分 类 号：Q78[生物学—分子生物学]