不同浓度丝裂霉素预防鼻泪管探通术后瘢痕形成的实验研究  

Experimental Study on the Preventive Effect of Different Concentrations of Mitomycin C on Scar Formation After Probing of Nasolacrimal Duct

作　　者：邵培红[1] 王艳华[1] 廉德花[1] 

机构地区：[1]滕州市中心人民医院眼科,山东滕州277500

出　　处：《护理学杂志》2006年第14期8-9,共2页

基　　金：山东省滕州市科技局科研基金资助项目(2002039)

摘　　要：目的探讨丝裂霉素(MMC)预防鼻泪管探通术后瘢痕形成的有效应用浓度。方法将36只兔随机分为A、B、C三组各12只,分别采用0.50%、0.10%、0.02%浓度MMC注入泪囊,于注射后14d、30d、3个月进行局部病理组织学观察。结果B、C组局部病理改变显著优于A组(均P<0.05),B组优于C组,但两组差异无显著性意义(均P>0.05)。结论0.10%MMC可有效抑制瘢痕形成,提高鼻泪管探通术成功率。Objective To find out the effective concentrations of mitomycin C in preventing scar formation after probing of nasolacrimal duct. Methods Thirty-six rabbits were divided into 3 groups, which were given the medicine at different concentrations of mitomycin C （0. 50% ,0.10% ,0.02%, respectively）. The pathological examinations of the local tissues were conducted 14 days, 30 days and 3 months after the injection. Results The pathological examination of local tissue showed better results in 0.10% mitomycin C group as compared with the other groups （P〈0. 05 for all）. Conclusion 0. 10% mitomycin C can effectively inhibit the scar formation and this ensures the success of the nasolacrimal probing.

关 键 词：鼻泪管阻塞 鼻泪管探通术 丝裂霉素 药物浓度 

分 类 号：R473.77[医药卫生—护理学]