绞股蓝总苷对免疫低下小鼠非特异性免疫功能的影响  

Effects of gypenosides to the immune deficit mouse's non-specific immunological function

作　　者：周俐[1] 叶开和[2] 任先达[2] 

机构地区：[1]广州市中医医院呼吸科,广东省广州510130 [2]暨南大学药学院药理教研室

出　　处：《中国基层医药》2006年第6期979-980,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨绞股蓝总苷免疫增强的药理作用,观察剂量效果关系。方法用绞股蓝总苷作为免疫增强剂治疗免疫低下小鼠模型,通过碳粒廓清实验观察非特异性免疫功能的变化。小鼠随机分为六组,模型组皮下注射环磷酰胺40mg/kg,制造免疫低下模型,与各对照组和药物高、中、低剂量组分别作碳粒廓清实验,观察各组非特异性免疫功能变化。结果模型小鼠廓清指数明显下降,阳性对照组,绞股蓝高、中剂量组非特异性免疫功能指标明显增强,作用强度相似。绞股蓝总苷的作用呈剂量依赖性。结论绞股蓝总苷能非常明显地增强非特异性免疫功能。Objective To explore the pharmacological function of immune enhancer of gypenosides and discuss the dose-effect relationship. Methods The gypenosides was used as an immune enhancer to cure the immune deficit mouse and observe non-specific immunological function by carbon clear test. All of the mice were administrat- ed with CTX and then were divided into six groups：control group, high dose group, middle dose group, lower dose group. Respectively,the carbon clear test was performed in each group and the variation of non-specific immune function was observed. Results The carbon clear test showed that the index of carbon clear test in control group was markedly decreased while the index of carbon clear testing high and middle group was increased. The effect of gypenosides was dose-dependent on the non-specific immune. Conclusion Gypenosides can markedly inerease the non-specific immune function.

关 键 词：绞股蓝总苷 碳粒廓清实验 免疫 

分 类 号：R285.5[医药卫生—中药学]