高渗氯化钠对健康人血液流变学影响的体外试验  

Effects of Hypertonic Saline on the Rheological Characteristics of Normal Human Blood

作　　者：卢家凯[1,2] 刘怀琼[1,2] 

机构地区：[1]北京军区总医院麻醉科 [2]第三军医大学大坪医院麻醉科

出　　处：《临床麻醉学杂志》1996年第6期307-309,共3页Journal of Clinical Anesthesiology

摘　　要：试验观察了不同浓度高渗氯化钠溶液（ＨＳ）对血液流变学特性的影响。结果：在高切变率（６３．９００ｓ－１）和低切变率（１．１８２ｓ－１）下，各高渗组随ＨＳ浓度提高，红细胞压积显著下降（Ｐ＜０．０１）；全血粘度均显著下降（Ｐ＜０．０１），组间全血粘度无显著差异（Ｐ＞０．０５），血浆粘度下降，但无统计学意义；红细胞聚集指数显著下降（Ｐ＜０．０１）；７．５％ＨＳ组红细胞刚性ＴＫ值增加，但无显著性，１５％ＨＳ和３０％ＨＳ组有显著提高（Ｐ＜０．０１）。结论：ＨＳ虽可增加红细胞刚性（变形性下降），但由于红细胞压积和血浆粘度下降导致的全血粘度下降，可在一定程度上补偿由于红细胞变形性下降给血液循环带来的不利影响。７．５％、４ｍｌ／ｋｇ是较合理的ＨＳ浓度和剂量选择。The present study observed the effects of hypertonic saline of different concentrations, 7 5%,15%,30%,respectively, on the profile of blood rheology under the condition of higher shear rate (63 900s -1 ) and lower shear rate (1 182s -1 ). The hematocrit of all groups treated with hypertonic saline decreased significantly. Although the viscosity value of both blood and plasma reduced in the presence of hypertonic saline, the viscosity of blood redcued significantly. No significant difference of the viscosity of blood and plasma was found among the groups treated with hypertonic saline. The aggregation index decredased significantly. The TK value revealed an increased tendency, and the significant difference could only be observed when comparing the groups of 15% and 30% hypertonic saline with the contral. The results suggest that the deformability of red blood cells decreases in the presence of hypertonic saline, but the reduction of viscosity of blood and plasma may counterbalance the disadvantages resulting from the reduction of red blood cells deformability of the systemic circulation. A concentration of 7 5% and dose of 4ml/kg are the reasonable choices for the use of hypertonic saline.

关 键 词：高渗氯化钠 血液流变学 体外试验 休克 

分 类 号：R977.7[医药卫生—药品]