通心络胶囊对冠心病心绞痛甲襞微循环和血液流变学变化的影响  

Effect of Tongxinluo capsule (通心络胶囊) on microcirculatory changes of nail bed and hemorrheology in patients with coronary artery disease and angina pectoris

作　　者：张素荣[1] 陈志刚[1] 吕风华[1] 张永春[1] 李红军[1] 袁宇[1] 黄陆力[1] 张卫国[1] 

机构地区：[1]新乡医学院第一附属医院心血管内科,河南卫辉453100

出　　处：《中国中西医结合急救杂志》2006年第4期237-239,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的:探讨通心络胶囊治疗冠心病心绞痛的疗效机制。方法:选择符合WHO诊断标准的冠心病心绞痛患者112例,随机分为治疗组60例和对照组52例。两组均服用β受体阻滞剂、硝酸脂等西药常规治疗;治疗组在常规治疗基础上加用通心络胶囊,每次2粒,每日2次,连服2个月。观察两组患者治疗前后临床疗效、心电图疗效、甲襞微循环积分值和血液流变学变化。结果:治疗组用药后临床疗效总有效率达86.67%,心电图疗效总有效率达80.00%,与对照组(78.85%和69.23%)比较差异均有显著性(P均<0.01);治疗组甲襞微循环和血液流变学各项指标变化均优于对照组(P均<0.01)。结论:通心络胶囊治疗冠心病心绞痛疗效显著,可明显改善临床症状,逆转心电图缺血变化,显著改善甲襞微循环和血液流变学指标。Objective： To investigate the mechanisms of curative effect of Tongxinluo capsule （通心络胶囊） on patients with coronary artery disease and angina pectoris. Methods： One hundred and twelve cases in accord with the diagnostic criteria of coronary heart disease of World Health Organization （WHO） were randomly divided into two groups： treatment group（n=60） and control group （n= 52）. The patients in both groups were treated with routine therapy including β- receptor retardant and ester of nitric acid etc. Additionally, the treatment group was treated with Tongxinluo capsules, 2 capsules each time and 2 times per day for 2 months consecutively. The clinical manifestations before and after treatment, the changes of electrocardiogram （ECG）, microcirculation of nail bed and hemorrheology were observed in all the patients in both groups. Results： The total clinical effective rate and the rate of total improvement in ECG changes were 86.67% and 80.00% respectively after treatment in the treatment group, and compared with the control group （78.85 % and 69.23 %） the differences were significant （both P〈0. 01）. All the signs of microcirculation nail bed and hemorrheology in the treatment group were superior to those of the control group （all P〈0. 01）. Conclusion： Tongxinluo capsule has significant therapeutic effect on angina pectoris in patients with coronary heart disease by remarkably improving clinical symptoms, ECG changes, microcirculation of nail bed and hemorrheologic signs.

关 键 词：通心络胶囊 冠心病 心绞痛 甲襞微循环 血液流变学 

分 类 号：R259[医药卫生—中西医结合]