氨氯地平片在健康人和高血压患者中的药物动力学  

The pharmacokinetics study of amlodipine in healthy volunteers and hypertension patients

作　　者：袁成[1] 焦素云[1] 王景祥[1] 

机构地区：[1]中国人民解放军济南军区总医院

出　　处：《中国医院药学杂志》1996年第10期435-437,共3页Chinese Journal of Hospital Pharmacy

摘　　要：采用反相高效液相色谱法测定了健康志愿者及高血压患者共３３名单剂量口服５ｍｇ苯磺酸氨氯地平片后的血清药物浓度，研究了该药在中国人体内的药物动力学。经ＰＫＢＰ－Ｎ１程序拟合表明，氨氯地平主要呈现二房室模型。其主要药动学参数分别为：健康人Ｔ１／２α＝０．６±０．５ｈ，Ｔ１／２β＝３５±９ｈ，Ｔｍａｘ＝８±４ｈ，Ｃｍａｘ＝２．４±０．８ｎｇ／ｍｌ；中青年高血压患者Ｔ１／２α＝０．６±０．４ｈ，Ｔ１／２β＝３６±９ｈ，Ｔｍａｘ＝１１±４ｈ，Ｃｍａｘ＝２．３±１．２ｎｇ／ｍｌ；老年高血压患者Ｔ１／２α＝０．４９±０．３３ｈ，Ｔ１／２β＝４２±１４ｈ，Ｔｍａｘ＝１０±４ｈ，Ｃｍａｘ＝２．８±１．４ｎｇ／ｍｌ。结果表明，中国人体内的氨氯地平药动学参数与报道的外国人相似。he concentration of anlodipine in serum was determined by high performance liquid chromatography.The pharmacokinetics of amlodipine was studied in 10 healthy volunteers,10 youth middle aged and 13 the aged hypertension patients.After oral amlodipine of 5mg,the data obtained were fitted with PKBP N1 program on computer.The results showed that the disposion of amlodipine was conformed to a two compartment model with T 1/2α = 0.6 ± 0.5 , 0.6 ± 0.4h and 0.49 ± 0.33h ; T 1/2β = 35 ± 9h , 36 ± 9h and 42 ± 14h ; T max = 8 ± 4h , 11 ± 4h and 10 ± 4h ; C max = 2.4 ± 0.8ng/ml , 2.3 ± 1.2ng/ml and 2.8 ± 1.4ng/ml ,and was absorbed rapidly,distributed widely in the body and also eliminated at a fairly rapid rate.

关 键 词：氨氯地平 药物动力学 高效液相色谱法 

分 类 号：R972[医药卫生—药品]