尿中1-羟基芘作为焦炉工多环芳烃暴露生物监测指标的研究  

Study on Urinary 1-hydroxypyrene concentrations in coke oven workers could be used as biomarker to evalute Polycyclic aromatic hydrocarbon exposure of coke oven workers

作　　者：王劲[1] 闫卫利[1] 郜舟顺[1] 李如田[1] 王适兴[1] 

机构地区：[1]天津市第三医院毒检中心,天津300250

出　　处：《河南预防医学杂志》2006年第3期138-139,150,共3页Henan Journal of Preventive Medicine

摘　　要：目的探讨焦炉工外暴露等级与尿中1-羟基芘(1-OHPy)浓度的关系。方法以某焦化厂120名生产工人和30名非接触者为研究对象,收集班后6h尿,并收集个人信息,用高效液相法测定尿中1-羟基芘。结果尿中1-羟基芘浓度呈炉顶>炉侧>炉底>对照组的趋势。与外暴露呈显著相关性(r=0.653,P<0.01),同样外暴露条件下,吸烟者尿中1-羟基芘显著高于未吸烟者(P<0.05)。结论焦炉工尿中1-羟基芘水平与外暴露等级存在明显的相关性,可反映多环芳烃暴露个体的内剂量水平。Objective TO investigate the relationship between the external exposure categories and urinary 1 -hydroxypyrene concentrations in coke oven workers. Methods 120 coke oven worker from a coke oven plant and 30 controls were enrolled into this study. Spot urine samples were obtained at the end of a work 6 hours and personal information was collected by quesfionnake. A method of alkaline hydrolysis combined with high performance liquid chromatography was employed to measure 1 - hvdroxypvrene in urine. Results Significant correlation was found between external exposure categories and urinary 1 -hydroxypyrene concentrations （Spearman correlation coefficient = 0. 653, P 〈 0. 01 ）. When adjsted for external exposure, smoking significantly influence urinary 1 - hydroxypyrene concentrations（ P 〈0. 01 ）. Conclusions There is a signficant association between external exposure categories and urinary 1 - hydroxypyrene concentrations in coke oven workers. Urinary 1 - hydroxypyrene concentrations in coke oven workers could be used aS biomarker to evaluate PAHs exposure of coke oven workers.

关 键 词：焦炉工 尿中1-羟基芘 多环芳烃 外暴露等级 

分 类 号：R134[医药卫生—劳动卫生]