注射用加替沙星与注射用阿昔洛韦配伍的稳定性考察及其红外光谱分析  

Stability Study and Infrared Spectrum Analysis on Gatifloxacin for Injection in Combination with Aciclovir for Injection

作　　者：杨继章[1] 刘瑞琴[1] 杨树民[1] 昝淑红[2] 

机构地区：[1]河北医科大学第一医院药剂科,石家庄市050031 [2]河北医科大学药学院,石家庄市050017

出　　处：《中国药房》2006年第14期1101-1103,共3页China Pharmacy

基　　金：河北省2004年医学科学研究重点课题(04177)

摘　　要：目的考察注射用加替沙星与注射用阿昔洛韦分别在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法在(20±1)℃条件下,分别观察和测定8h内配伍液的外观、pH值变化,并对配伍液中沉淀物进行红外光谱分析。结果第1h内配伍液出现白色絮状沉淀,用红外光谱分析沉淀为一新物质。结论注射用加替沙星与注射用阿昔洛韦存在配伍禁忌。OBJECTIVE： To study the compatible stability of gatifloxacin for injection in combination with aciclovir for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS： Changes in appearance and pH value of gatifloxacin in combination with aciclovir within 8 hours after mixing were observed and determined under room temperature（20± 1）℃, respectively, and the precipitates in the mixture underwent infrared spectrum analysis.RESULTS： White flocculent precipitate was noted in the mixture within 1 hour of mixing,which was proved as a new substance by infrared spectrum analysis. CONCLUSIONS：There is incompatibility between gatifloxacin for injection and aciclovir for injection.

关 键 词：加替沙星 阿昔洛韦 配伍 稳定性 红外光谱 

分 类 号：R927.11[医药卫生—药学]