樟脑对水杨酸和氟脲嘧啶的促皮渗透作用  

THE ENHANCING EFFECTS OF CAMPHOR ON SKIN PERMEATION OF SALICYLIC ACID AND ELUOROURACIL

作　　者：刘郴淑[1] 许碧莲[1] 何康[1] 

机构地区：[1]广东医学院附属医院药剂科,广东医院药理学教研室

出　　处：《广东医学院学报》1996年第4期320-321,共2页Journal of Guangdong Medical College

摘　　要：用两室扩散地位外透皮实验装置研究樟脑对水杨酸和氟尿嘧啶（５－ＦＵ）透皮吸收的影响。实验结果表明：（１）含３％樟脑或３％月桂氮草酮（Ａｚｏｎｅ）的１．Ｏ％水杨酸醇溶液２４ｈ透皮吸收率分别为３６．４±３．６％和３８．４±４．４％；不含助渗剂的对照组２４ｈ透皮吸收率为２２．４±２．２％。（２）含３％樟脑或３％Ａｚｏｎｅ的０．５％５－Ｆｕ醇溶液２４ｈ透皮吸收率分别为３７．６±４．３％和４５．６±２．７％；不含助渗剂的对照组２４ｈ透皮吸收率为２０．７±４．４％。提示樟脑对水杨酸和氟尿嘧啶有促皮渗透作用。The effect of camphor on percutaneous absorption of the salicylic acid and fluorouracil(5-Fu)was investigated by two cells diffusion apparatus in vitro. The results showed that the penetration percentage of the salicylic acid mixed with 3% camphor or 3% Azone was 36.4±3.6%,38.4±4.4% in 24 hrs respectiavely, while that of salicylic acid alone was 22.4±2.2%;and the penetration percentage of 5-Fu mixed with 3% camphor or 3% Azone was 37.6±4.3%,45.6±2.7% in 24 hrs. respectively, while that of 5-Fu alone was 20.7±4.4%,These data indicate that the camphor has the effect of pentration enhancer on skin permeation of salicylic acid and 5-Fu.

关 键 词：樟脑 水杨酸 氟脲嘧啶 透皮吸收 

分 类 号：R944.9[医药卫生—药剂学]