Investigation of the Elasticity of Polymer Nanoparticle by Vibrating Scanning Polarization Force Microscopy  

作　　者：张立娟 王化斌 

机构地区：[1]Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 [2]Graduate School of the Chinese Academy of Sciences, Beijing 100049

出　　处：《Chinese Physics Letters》2006年第8期2315-2318,共4页中国物理快报（英文版）

基　　金：Supported by the 100 Persons Project of the Chinese Academy of Sciences, the National Natural Science Foundation of China under Grant No 10474109, the Foundation of Ministry of Personnel of China.

摘　　要：The elasticity of an individual polymer nanoparticle may be greatly different from that of the bulk one. Understanding the properties of individual particles such as elasticity and deformation under external forces is of great importance in controlling the final structures and functions of bulk materials. We study the compression properties of single polyethylenimine （PEI） particles using vibrating scanning polarization force microscopy. By controllably imaging PEI particles at different vibration amplitude set-point values, it is demonstrated that we can compress the single PEI nanoparticle with an atomic force microscopy tip in different loads. Based on the force-height and force-strain curves obtained, Young＇s moduli of PEI （5-160 MPa） in three force regions are estimated according to the Hertz model The results indicate that PEI has excellent elasticity, which may contribute to its high efficiency as vectors in gene transfection.The elasticity of an individual polymer nanoparticle may be greatly different from that of the bulk one. Understanding the properties of individual particles such as elasticity and deformation under external forces is of great importance in controlling the final structures and functions of bulk materials. We study the compression properties of single polyethylenimine （PEI） particles using vibrating scanning polarization force microscopy. By controllably imaging PEI particles at different vibration amplitude set-point values, it is demonstrated that we can compress the single PEI nanoparticle with an atomic force microscopy tip in different loads. Based on the force-height and force-strain curves obtained, Young＇s moduli of PEI （5-160 MPa） in three force regions are estimated according to the Hertz model The results indicate that PEI has excellent elasticity, which may contribute to its high efficiency as vectors in gene transfection.

关 键 词：CARBON NANOTUBES GENE DELIVERY POLYETHYLENIMINE COMPRESSION MACROMOLECULES RESOLUTION STIFFNESS VECTOR CELLS 

分 类 号：O343[理学—固体力学]