土家族药物天葵化石汤提取液抑制草酸钙结石形成的化学模拟  

Chemical Simulation on Inhibition of Calcium Oxalate Stone by the Extract from a Traditional Chinese Medicine Tiankui Soup

作　　者：柳一鸣[1] 欧阳健明[1] 邓芳[1] 郑辉[1] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,广州510632

出　　处：《化学学报》2006年第14期1446-1450,共5页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20471024);广东省科技攻关项目(No.2005B30701003);国家自然科学基金重点项目(No.20031010);教育部留学基金(教外司[2005]55号)资助项目.

摘　　要：采用扫描电子显微镜(SEM)和X射线衍射法(XRD)研究了土家族药物天葵化石汤(Tiankui)的提取液对尿石晶体草酸钙(CaOxa)成核、生长的抑制作用及其对二水草酸钙(COD)的稳定作用.当Tiankui浓度小于30mg/mL时,主要生成一水草酸钙(COM),但可使COM晶体棱角圆钝.随着Tiankui浓度增加至45和75mg/mL,可分别诱导95%和100%的COD晶体生成.Tiankui还可以稳定COD在水溶液中的存在,没有Tiankui存在时,COD在48h内全部转化为COM晶体,而在12mg/mLTiankui存在下,COD仅有20%转化.从Tiankui提取液的活性组分、与草酸钙不同晶相间的吸附差异、化学配位等角度讨论了其抑制CaOxa生长和诱导稳定COD的化学基础.The inhibition to nucleation and growth of urinary crystal calcium oxalate （CaOxa） crystallization and the stabilization to calcium oxalate dihydrate （COD） by an aqueous extract from Tiankui soup, a Chinese traditional medicine from Tujiazu, were studied by scanning electron microscopy （SEM） and X-ray diffration （XRD）. When the amount of Tiankui was less than 30 mg/mL, only calcium oxalate monohydrate （COM） crystals were grown. When the amount of Tiankui was 45 and 75 mg/mL, COD crystals were induced, and the percentage of COD was 95% and 100%, respectively. The extract from Tiankui can stabilize the existence of COD crystals. In pure water, COD transformed to COM crystals in 48 h, while only 20% of the COD was transformed in the presence of 12 mg/mL of Tiankui. These chemical basis about the inhibition to CaOxa growth and about the induction and stabilization to COD crystals were explained in terms of the active constituents of the extract, the adsorption difference of the constituents with calcium oxalate crystals, and the coordination of the constituents with Ca^2＋ ions.

关 键 词：草酸钙 结晶 尿结石 中草药 

分 类 号：R29[医药卫生—民族医学]