副流感病毒小鼠动物模型的建立及病理学研究  

Pathology Study and Model Foundation of Parainfluenza Virus Infection in Mice

作　　者：杜淑娟[1] 程树军[2] 袁美凤[1] 

机构地区：[1]广东省中医院,广州510120 [2]广东检验检疫技术中心,广州510623

出　　处：《中国比较医学杂志》2006年第7期387-389,F0002,共4页Chinese Journal of Comparative Medicine

摘　　要：目的建立副流感病毒感染的小鼠动物模型,为中医中药抗病毒研究提供模型动物。方法选择与副流感病毒抗原关系密切的仙台病毒感染NIH、BALB/c和KM三个品系小鼠,观察不同品系的动物对仙台病毒的敏感性和组织学差异。结果KM小鼠感染仙台病毒,病程适中,临床症状明显,病理变化典型,是仙台病毒感染的理想品系。结论KM小鼠感染仙台病毒可作为副流感病毒感染的疾病模型,应用于药理学等生物医学研究中。Objective To establish a parainfluenza-virus-infective model in mice and to provid model animals for anti-virus research of TCM. Method NIH, BALB/c and KM mice were infected by Sendia virus （SV）, whose antigen were closed to parainfluenza virus. Then the change of histopathological was observed. Result The KM mice was an ideal strain for SV infection for its moderate infection duration, obvious clinical symptoms and typical lesion. Conclusion SV-infected KM mice can be used in model of anti-parainfluenza virus infected disease and pharmacology researches.

关 键 词：仙台病毒 副流感病毒 模型 动物 

分 类 号：R56[医药卫生—呼吸系统]