硫酸钙作为微小颗粒骨载体的实验研究  

Study on calcium sulphate as the carrier of the autogenous micromorselized bone

作　　者：刘欣[1] 贾广义[1] 闫景龙[2] 

机构地区：[1]哈尔滨市第一医院,150010 [2]哈尔滨医科大学附属第一医院,150001

出　　处：《现代生物医学进展》2006年第6期39-40,46,共3页Progress in Modern Biomedicine

摘　　要：目的:研究硫酸钙作为微小颗粒骨载体,解决微小颗粒骨的自身缺点的实际效果,为其临床应用提供依据。方法:将49只日本大耳白兔随机分成4组并通过手术造成双侧桡骨中段1.5cm骨缺损,以植入硫酸钙为载体的自体微小颗粒骨为实验组,同时设立单纯植入自体微小颗粒骨,单纯植入硫酸钙和不植入任何物质的空白对照组。术后4周和8周分别行大体观察,X线摄片,组织学观察,骨生物力学测定。结果:以硫酸钙为载体的自体微小颗粒骨组比单纯自体微小颗粒骨组及单纯硫酸钙组能更有效地修复骨缺损,单纯颗粒骨组成骨效果优于单纯硫酸钙组。空白组无骨愈合迹象;组织学观察示以硫酸钙为载体的自体微小颗粒骨实验组的成骨效果最好,单纯自体微小颗粒骨组次之;生物力学测定证明以硫酸钙为载体的自体微小颗粒骨实验组的力学强度优于单纯自体微小颗粒骨组及单纯硫酸钙组。结论:硫酸钙是微小颗粒骨的优良载体,以硫酸钙为载体的自体微小颗粒骨成骨速度快,成骨量多,质量高,骨的机械强度高,修复骨缺损的能力较单纯应用微小颗粒骨和硫酸钙强;二者结合可充分发辉各自的优势。Objective： To probe the ability of the calcium sulphate as the carder of the autogenous micromorselized bone, to solve the defects of micromorselized bone, and to provide the prod for the clinic. Methods： The animal models of bilateral radius bone defect were created by surgery in Japan white big ear rabbits, the experimental group was implanted the autogeaous micromorselized bone whose carder is calcium sulphate, while in the control groups, some was implanted the autogenous micromorselized bone, some was implanted the calcium sulphate, and others was implanted nothing. The bone defect were observed by gross examination, X- ray examination, histopatholgical examination and biomechanics＇ determination at 4,8W. Results： The experimental group repaired the bone defect more effectually than the control group. In the control group, autogenous micromorselized bone did better than calcium sulphate and there is no phenommenon of healing in the group implanted nothing. The quality and rate of the new formation bone in the examination group was the best. The effect of biomechanics in the examination group was statistically significant different with the group implanted the autogenous micromorselized and the group implanted the calcium sulphate. Conclusion： The calcium sulphate is the good carder d the autogenous micromorselized bone. The autogenous micromorselized bone carried by calcium sulphate forms more bone, whose quality, rate anti biomechanica is excellent, anti has more ability of repairing the bone defect than the group implanted the aulogenous micromorselized bone or calcium sulphate.

关 键 词：颗粒骨 硫酸钙 载体 

分 类 号：R322.7[医药卫生—人体解剖和组织胚胎学]