不同剂量^(60)Co-γ射线辐照对三黄片中大黄粉含量及消毒效果的影响  

INFLUENCE OF DIFFERENT DOSAGES OF ^(60)CO-γ IRRADIATION ON RHUBARB (RADIX ET RHIZOMA RHEI) POWDER CONTENT IN SAN-HUANG TABLET AND DISINFECTION EFFICACY

作　　者：李奉勤[1] 马振嗣[1] 史冬霞[1] 张瑞红[1] 苏平菊[1] 范文成[1] 

机构地区：[1]石家庄以岭药业股份有限公司,石家庄050035

出　　处：《中国消毒学杂志》2006年第4期317-318,共2页Chinese Journal of Disinfection

摘　　要：为了解不同辐射剂量60Co-γ射线辐照灭菌对三黄片主要成分大黄素、大黄酚含量及消毒效果的影响,采用高效液相色谱法及细菌检验方法,对辐照处理的三黄片中大黄素、大黄酚和辐照消毒效果进行了检测。结果,三黄片经不同辐照剂量60Co-γ射线辐照前后,其主要成分大黄素、大黄酚的含量无明显的变化;辐照剂量为2 kGy的照度下即可以达到消毒要求。结论,三黄片用60Co-γ射线辐照消毒方法对其有效成分基本无影响,消毒效果可靠。In order to know the influence of different dosages of ^60Co - γ irradiation on chrysophanol and emodin con - tents, the main components of San - Huang Tablet, and the disinfection efficacy, high - performance liquid chromatography and bacteriological examination method were used to determine chrysophanol and emodin contents in irradiated San - Huang Tablet and efficacy of irradiation disinfection. Results： The main components chrysophanol and emodin contents of San - Huang Tablet before and after irradiation with different dosages of ^60Co - γ rays did not change significantly. Even 2 kGy irradiation could fulfil disinfection requirement. Conclusion： Disinfection of San - Huang Tablet with ^60Co - γ irradiation essentially did not influence its active components and the efficacy of disinfection was reliable.

关 键 词：三黄片 大黄素 大黄酚 高效液相色谱 辐照消毒 

分 类 号：R187.2[医药卫生—流行病学]