神经突起导向因子netrin-1及其受体与肿瘤发生  

Axon Guidance Factor Netrin-1 and Its Receptors in Tumorigenesis

作　　者：秦树桐[1] 张成岗[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京市100850

出　　处：《医学分子生物学杂志》2006年第4期300-304,共5页Journal of Medical Molecular Biology

基　　金：国家重点基础研究发展计划(973计划)(No.2003CB715900);国家自然科学基金面上项目(No.30500147)~~

摘　　要：近年来的研究发现,netrin1和其受体基因在多种肿瘤中表达下调,未与配体netrin1结合的DCC和UNC5H能够诱导细胞凋亡,而在结合配体后则抑制细胞凋亡。在肿瘤细胞中凋亡通路通常被抑制,而且在50%以上的肿瘤中p53是失活的。netrin1与其受体结合后能完全抑制p53诱导的细胞凋亡;同时p53也直接调节netrin1及其受体基因的表达。因此,netrin1及其受体可能在肿瘤发生过程中发挥重要作用。Recent studies showed that the expression of netrin-1 and its receptors were downregulated in a number of tumors when compared with corresponding normal tissues. Apoptosis would be induced by DCC and UNCSH in the absence of netrin-1, but it inhibited the apoptosis in the presence of netrin-1. It is well known that the apoptosis pathway is frequently inhibited in tumors and p53 is inactivated in more than 50% of tumors. Surprisingly, binding of netrin-1 to its receptors DCC and UNCSH completely inhibited p53-dependent apoptosis. A more recent evidence was that p53 directly regulated the transcription of netrin-1 and its receptors. Accordingly, it is believed that netrin-1 and its receptors may play an important role in tumorigenesis.

关 键 词：神经突起导向因子 UNC5同源蛋白 肿瘤发生 细胞凋亡 

分 类 号：Q291[生物学—细胞生物学]