机械生长因子的结构与调节  

Structure and Regulation of Mechano Growth Factor

作　　者：史仍飞[1] 危小焰[1] 

机构地区：[1]上海体育学院运动科学学院,上海市200438

出　　处：《医学分子生物学杂志》2006年第4期316-319,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.10572097);上海市自然科学基金(05ZR14111);上海市第二期重点学科建设项目(No.T0901)~~

摘　　要：机械生长因子(mechanogrowthfactor,MGF)起源于胰岛素生长因子Ⅰ(insulinlikegrowthfactorⅠ,IGFⅠ),与肝型IGFⅠ基因有着不同的3′端序列。MGF的表达主要受机械剌激和局部组织损伤的影响,且比肝型IGFⅠ具有增加肌肉质量的能力;机械刺激后幼年骨骼肌MGF表达先于其它IGFⅠ异构体,且MGFmRNA水平与年龄及生长激素有密切关系。Mechano Growth Factor （MGF） is derived from the insulin-like growth factor （IGF- Ⅰ ）, and has a 3＇-sequence and a mode of action that are different from liver IGF- Ⅰ . MGF is expressed by mechanically overloaded muscle and is involved in tissue repair. Moreover, MGF is very potent and much more effective in increasing muscle mass than the liver IGF- Ⅰ . Following mechanical strain and/or muscle damage , the expression of young bone muscles fakes place befor the other IGF-Ⅰ, and MGF mRNA levels bear a close relationship with age and growth hormone

关 键 词：机械生长因子 生长激素 骨骼肌 运动 

分 类 号：R872[医药卫生—运动医学]