腺苷脱氨酶、C-反应蛋白与癌胚抗原检测对胸腔积液的诊断价值  

Diagnosis value of adenosine deaminase,C-reactive protein and carcinoembryonic antigen detection for pleural effusion

作　　者：戴素俊[1] 施明美[1] 胡江[1] 夏峰[1] 

机构地区：[1]中国十七冶医院检验科,安徽马鞍山243000

出　　处：《蚌埠医学院学报》2006年第4期422-423,共2页Journal of Bengbu Medical College

摘　　要：目的探讨胸腔积液中腺苷脱氨酶(adenosinedeaminase,ADA)、C-反应蛋白(C-reactiveprotein,CRP)、癌胚抗原(carcinoembryonicantigen,CEA)的检测在胸腔积液鉴别诊断中的意义。方法以氨试剂法、散射比浊法和微粒子化学发光法分别检测39例结核性胸腔积液、18例恶性胸腔积液的ADA、CRP和CEA。结果以胸腔积液ADA≥40IU/L、CRP≥10mg/L和CEA<15μg/L等单项指标为判断标准诊断结核性胸腔积液,其敏感性为95.2%,特异性为97.6%;以ADA<40IU/L、CRP<10mg/L和CEA≥15μg/L等单项指标为判断标准诊断恶性胸腔积液,其敏感性为94.9%,特异性为96.7%。结论联合检测ADA、CRP和CEA为提高胸腔积液的鉴别诊断提供了可靠的实验依据。Objective ：To investigate the differential diagnosis value of adenosine deaminase （ADA）, C-reactive protein （CRP） and carcinoembryonic antigen（CEA） detection in pleural effusion. Methods：ADA,CRP and CEA were detected using colorimetric assay, nephelometric assay and automated chemiluminescent immunoassay in 39 samples of tuberculosis effusion and 18 samples of malignant effusion, Results：The criteria for diagnosis of tuberculosis pleural perfusion were that ADAm〉40 IU/L,CRP≥10 mg/L and CEA 〈 15 μg/L. The sensitivety and specificity of ADA, CRP and CEA in combination were 95.2% and 97.6% for diagnosing tuberculosis effusion. The criteria for diagnosis of tuberculosis pleura] perfusion were that ADA 〈 40 IU/L, CRP 〈 10 mg/L and CEA ≥ 15 μg/L. The sensitivety and specificity of ADA, CRP and CEA in combination were 94.9% and 96.7% for diagnosis of malignant effusion. Conelusions：ADA ,CRP and CEA in combination are useful parameters for differential diagnosis of pleural effusion.

关 键 词：胸腔积液 免疫学技术 腺苷脱氨酶 C-反应蛋白 癌胚抗原 诊断 鉴别 

分 类 号：R561.3[医药卫生—呼吸系统] R446.61[医药卫生—内科学]