与短期塞来考昔应用相关的持续性胆汁淤积症  

Prolonged cholestasis associated with short-term use of celecoxib

作　　者：Chamouard P. Walter P. Baumann R. Poupon R. 王顺涛(译) 郑世成(校) 

机构地区：[1]不详 [2]Service d'Hepato-Gastroenterologie,Hopital de Hautepierre, 67098 Strasbourg Cedex

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第6期31-31,共1页Core Journals in Gastroenterology

摘　　要：Drug-induced liver injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported. We describe one case of severe and prolonged cholestasis after treatment with celecoxib for 12 days in a young woman with no evidence of other causes of liver disease or allergy. Jaundice lasted for 3 months, pruritus and abnormal liver biochemistries persisted for 18 months after stopping the drug. Liver biopsy specimens showed a cholestatic pattern of liver injury with only minimal mononuclear infiltrate in the portal tracts. This case report supports the notion that celecoxib may cause bland, long term cholestasis.Drug-induced liver injury due to celecoxib, a first generation Cox- 2 inhibitor, has been rarely reported. We describe one case of severe and prolonged cholestasis after treatment with celecoxib for 12 days in a young woman with no evidence of other causes of liver disease or allergy. Jaundice lasted for 3 months, pruritus and abnormal liver biochemistries persisted for 18 months after stopping the drug. Liver biopsy specimens showed a cholestatic pattern of liver injury with only minimal mononuclear infiltrate in the portal tracts. This case report supports the notion that celecoxib may cause bland, long term cholestasis.

关 键 词：胆汁淤积症 塞来考昔 持续性 药物性肝损伤 单核细胞浸润 女性患者 肝脏疾病 环氧合酶 生化异常 肝脏活检 

分 类 号：R714.255[医药卫生—妇产科学] R684.3[医药卫生—临床医学]