与塞来考昔治疗密切相关的急性大肠炎  

Acute colitis closely following the beginning of celecoxib treatment

作　　者：Houmani Z. Imbert A. Duchmann J. -C. 王顺涛(译) 郑世成(校) 

机构地区：[1]Service d'Hepato-Gastroenterologie, Centre Hospitalier, 8 avenue Henri Adnot, 60321 Compiegne Cedex [2]不详

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第6期31-31,共1页Core Journals in Gastroenterology

摘　　要：Selective inhibitors of cyclooxygenase-2 have less gastroduodenal toxicity than non selective anti-inflammatory drugs. However, there is little information on their effect on the distal gut. A 91 year old woman presented with acute diarrhoea 5 weeks after beginning celecoxib treatment. Laboratory results showed an inflammatory syndrome and increased alanine aminotransferase (ALT) to 13 N. Endoscopic examination of the colon showed diffuse erythematous lesions of the sigmoid and of part of the right colon. No aetiology has been found for colitis or hepatitis. Diarrhea and blood test anomalies disappeared one week after celecoxib was stopped. The role of celecoxib in the etiology of colitis was considered plausible but not for liver damage. This report and a few other cases in the literature suggest that cyclooxygenase-2 selective non-steroidal anti-infla-mmatory drug inhibitor toxicity should be investigated in case of unexplained acute colitis.Selective inhibitors of cyclooxygenase - 2 have less gastroduodenal toxicity than non selective anti-inflammatory drugs. However, there is little information on their effect on the distal gut. A 91 year old woman presented with acute diarrhoea 5 weeks after beginning celecoxib treatment. Laboratory results showed an inflammatory syndrome and increased alanine aminotransferase （ALT） to 13 N. Endoscopic examination of the colon showed diffuse erythematous lesions of the sigmoid and of part of the right colon. No aetiology has been found for colitis or hepatitis. Diarrhea and blood test anomalies disappeared one week after celecoxib was stopped. The role of celecoxib in the etiology of colitis was considered plausible but not for liver damage This report and a few other cases in the literature suggest that cyclooxygenase-2 selective non-steroidal anti-inflammatory drug inhibitor toxicity should be investigated in case of unexplained acute colitis.

关 键 词：塞来考昔 大肠炎 COX-2选择性抑制剂 急性 治疗 结肠内镜检查 女性患者 腹泻症状 毒性作用 胃十二指肠 

分 类 号：R684.3[医药卫生—骨科学] R574.6[医药卫生—外科学]