丙型肝炎相关的基因表达模式与肝移植受体早期进展为肝纤维化有关  

Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients

作　　者：Smith M. W. Walters K. -A. Korth M. J. M.G. Katze. 成虹(译) 陈云茹(校) 

机构地区：[1]不详 [2]Department of Microbiology, University of Washington, Box 358070, Seattle, WA 981958070, United States

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第6期36-37,共2页Core Journals in Gastroenterology

摘　　要：Background &Aims: Liver transplant recipients infected with hepatitis C virus (HCV) develop recurrent hepatitis soon after transplantation and, in some cases, progress to fibrosis within the first 2 years. Our goals were to identify molecular processes influencing the liver disease progression and to find potential gene markers of early fibrosis. Methods: We performed gene expression profiling on serial liver biopsy specimens obtained from 13 (11 infected and 2 uninfected) transplant recipients within the first year after transplantation at 0, 3, 6, and 12 months. The data were compared with clinical observations and with a gene expression database obtained for 55 nontransplant HCV-infected and uninfected liver samples. Results: We identified several specific gene expression patterns. The first pattern was unique for the transplant recipients regardless of their infection status. The corresponding genes encoded stress response proteins and blood proteins involved in coagulation that were differentially expressed in response to posttransplantation graft recovery. The second pattern was specific to HCV-infected samples and included up-regulation of genes encoding components of the interferon-mediated antiviral response and immune system (antigen presentation, cytotoxic response). This upregulation pattern was absent or suppressed in the patients who developed early fibrosis, indicating that the disease progression might result from an impaired liver response to infection. Finally, we identified gene expression patterns that were specific for 12-month biopsy specimens in all 4 HCV-infected patients who developed early fibrosis. Conclusions: The identified gene expression patterns may prove useful for diagnostic and prognostic applications in HCV-infected patients, including predicting early progression to fibrosis.Background ＆ Aims： Liver transplant recipients infected with hepatitis C virus （HCV） develop recurrent hepatitis soon after transplantation and, in some cases, progress to fibrosis within the first 2 years. Our goals were to identify molecular processes influencing the liver disease progression and to find potential gene markers of early fibrosis. Methods： We performed gene expression profiling on serial liver biopsy specimens obtained from 13 （11 infected and 2 uninfected） transplant recipients within the first year after transplantation at 0, 3, 6, and 12 months. The data were compared with clinical observations and with a gene expression database obtained for 55 nontransplant HCV-infected and uninfected liver samples. Results： We identified several specific gene expression patterns. The first pattern was unique for the transplant recipients regardless of their infection status. The corresponding genes encoded stress response proteins and blood proteins involved in coagulation that were differentially expressed in response to posttransplantation graft recovery. The second pattern was specific to HCV-infected samples and included up-regulation of genes encoding components of the interferon-mediated antiviral response and immune system （antigen presentation, cytotoxic response） . This upregulation pattern was absent or suppressed in the patients who developed early fibrosis, indicating that the disease progression might result from an impaired liver response to infection.

关 键 词：丙型肝炎病毒(HCV) 早期肝纤维化 基因表达模式 肝移植受体 肝移植术后 肝活检标本 非感染者 基因表达分析 基因编码 疾病进展 

分 类 号：R511[医药卫生—内科学] R575.2[医药卫生—临床医学]