乙肝病毒前S2抗原的临床应用  

Clinical Implication of Pre-s2 Antigen of Hepatitis B Viruses

作　　者：蔡常辉[1] 陈桂山[1] 梁锦胜[1] 

机构地区：[1]广东省中山市人民医院,广东中山528403

出　　处：《实用预防医学》2006年第4期864-865,共2页Practical Preventive Medicine

摘　　要：目的探讨乙型肝炎病毒前S2抗原(Pre-S2)检测在临床中的应用价值。方法将253例乙型肝炎患者标本用酶联法(ELISA)检测Pre-S2、乙型肝炎病毒(HBV)标记物,荧光定量PCR法检测乙型肝炎病毒DNA(HBVD-NA)。结果HBeAg阳性组Pre-S2、HBVDNA阳性率各为95.3%、97.6%;抗-HBe阳性组Pre-S2、HBVDNA阳性率各为58.1%、31.2%;e系统阴性组Pre-S2、HBVDNA阳性率各为74.7%、45.3%。结论乙型肝炎患者Pre-S2与HBeAg、HBVDNA呈伴随关系,是HBV复制活跃和疗效观察的良好指标;抗-HBe阳性及e系统阴性乙型肝炎患者Pre-S2检出率偏高有待探讨。Objective To study the clinical significance of Pre - s2 antigen of hepatitis B viruses （HBV）. Methods Pre - S2 antigen, HBV markers （HBV M） of 253 patients with chronic hepatitis B were examined by ELISA, HBVDNA and fluorescent- quantitative PCR. Results The positive rates of Pre - S2 antigen and HBVDNA in HBeAg positive group were 95,3 % and 97.5 % respectively, 58.1%, and 31.2 % respectively in anti - HBe positive group, 74.7 % and 45.3 % respectively in both HBeAg and anti- HBe negative group. Conclusions Pre - S2 antigen is related with HBeAg and HBVD- NA,and being a good indicator for viral replication and infection burden in chronic hepatitis B patients. The positive rates of Pre- S2 antigen in anti- HBe positive group and both HBeAg and anti- HBe negative group were higher, and the causes warrant studied further.

关 键 词：PRE-S2 HBVDNA HBEAG 抗-HBE 

分 类 号：R512.62[医药卫生—内科学]