托烷司琼不同时间给药预防术后恶心呕吐的效果  

Prophylaxic effects of tropisetron on postoperative nausea and vomiting

作　　者：秦丽文[1] 郑良杰[1] 郝国明[1] 张舟[1] 张长椿[1] 吴萍[1] 

机构地区：[1]广东省汕头市中心医院,中山大学附属汕头医院麻醉科,515031

出　　处：《实用医学杂志》2006年第16期1925-1926,共2页The Journal of Practical Medicine

摘　　要：目的:观察托烷司琼不同时间给药对预防病人术后恶心呕吐的效果。方法:将90例在静吸复合全身麻醉下行腹腔镜胆囊切除术的病人随机分为3组,每组30例。托烷司琼术前组(Ⅰ组),于麻醉诱导前给予托烷司琼5mg;托烷司琼术后组(Ⅱ组),于手术结束时给予托烷司琼5mg;对照组(Ⅲ组),不给予托烷司琼。观察记录病人术后24h恶心呕吐发生情况。结果:Ⅰ组恶心、呕吐发生率为27%和20%,Ⅱ组病人恶心、呕吐的发生率为30%和23%,Ⅰ组与Ⅱ组比较差异无显著性(P>0.05),Ⅲ组恶心、呕吐发生率为50%和37%,Ⅲ组与Ⅰ组、Ⅱ组比较差异有显著性(P<0.05)。结论:托烷司琼术前和术后不同时间给药,在剂量相同的条件下,均能有效地减少术后病人恶心、呕吐的发生,术前预防性给药效果更优。Objective To observe the prophylactic effect of tropisetron on postoperative nausea and vomiting(PONV). Methods Ninety patients scheduled for celioscope cholecystectomy under intravenous-inhalation general anesthesia were randomly divided into three groups,preoperative group(GroupⅠ, n=30):tropisetron was given prior to the inductionof anesthesia, postoperative group(GroupⅡ, n=30) :tropisetron was given at the end of the surgery and control group(GroupⅢ, n=30):no tropisetron was given. The incidence of nausea and vomiting was observed and recorded during 24h after surgery. Results The frequency of nausea and vomiting was 27%and 20%in GroupⅠ, 30%and 23%in GroupⅡand 50%and 37%in Group Ⅲ. There was no significantly difference between GroupⅠand GroupⅡ(P >0.05) and were significantly differences between Group Ⅲand GroupⅠor GroupⅡ(P< 0.05 and 0.05). Conclusion Under the same dose, tropisetron given either before surgery or after surgery can effectively reduce the incidence of postoperative nausea and vomiting, of which the former is better than the latter.

关 键 词：手术后恶心呕吐 胆囊切除术 腹腔镜 全麻 托烷司琼 

分 类 号：R614[医药卫生—麻醉学]