青木香生品及其炮制品的毒理学研究  

Toxicologically studies of raw radix aristolochiae and it′s processed product

作　　者：姜旭[1] 李琳[1] 王维皓[1] 王金华[1] 高慧敏[1] 王智民[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国药物与临床》2006年第7期485-487,共3页Chinese Remedies & Clinics

基　　金：国家自然科学基金资助项目(30271612);国家中医药管理局资助项目(02-32zp59)

摘　　要：目的通过青木香生品和炮制品的急性毒性和长期毒性实验,比较生品和炮制品的毒性。方法采用小鼠急性毒性实验、大鼠长期毒性实验。结果青木香生品饮片半数致死剂量(LD50)为146.45g/kg,炮制品饮片LD50为846.06g/kg;长期毒性生品大中小3个剂量用药1个月后出现毒性反应,炮制品3个剂量组毒性反应较小。结论青木香用碱醋炮制可达到减毒目的。Objective To compare the toxicity of the raw and processed product of radix aristolochiae,acute toxicity and long-term safety evaluation were done. Methods Acute toxicity in rats and long-term safety evaluation in mouse were done. Results LD50 of raw radix aristolochiae and processed products were 146.45 and 846.06 g materials /kg respectively.Long-term safety evaluation shower the processed products had lower toxicity. Conclusion All these results indicated that the toxicity of the processed product were much lower than that of the raw material.

关 键 词：青木香 炮制品 毒理学 

分 类 号：R285[医药卫生—中药学]