西地那非联合帕罗西汀治疗难治性早泄  

The combined treatment of refractory premature ejaculation with sildenafil and paroxetine

作　　者：钱余[1] 夏仁惠[1] 刘剑新[1] 周伟邦 田长海[1] 蒋跃庆[2] 

机构地区：[1]上海市中西医结合医院泌尿外科,上海200082 [2]上海交通大学附属第九人民医院泌尿外科

出　　处：《中国男科学杂志》2006年第7期41-43,共3页Chinese Journal of Andrology

基　　金：上海市虹口区卫医学生系统医学科研项目(2003009)

摘　　要：目的评价两地那非联合帕罗西汀治疗难治性早泄的临床疗效。方法评估指标：早泄指数(PE) 0～8分(没有=0分,几乎每次=8分),阴道内射精潜伏期评分(1VELT评分)0～3分(超过5min=0分,小于lmin=3分),并记录配偶性交满意频度(SSR)。本组共28例,口服帕罗西汀片剂20mg,每天1次,连续4周为1疗程,性交前2～3h口服两地那非50mg；疗程共3次(持续约4月余),全部病例完成用药并获随访。用药前及3月后分别评估病人早泄指数、IVELT评分,记录阴道内射精潜伏时间和配偶性交满意频度。结果治疗前早泄指数平均为5．69±0．13,IVELT评分为2．81±0．21,治疗后早泄指数平均为1．77±0．22,IVELT为0．16±0．36。治疗前后比较差异均有统计学意义(P＜0．01)。早泄改善者共26例,总有效率为92．86%,其中22例(78．26%)显效。不良反应未经特殊处理自动缓解。结论两地那非与帕罗西汀联合应用能明显改善难治性早泄患者的临床症状。Objectives To evaluate the efficacy of sildenafil and paroxetine in alleviating refractory premature ejaculafion（PE）. Methods PE was graded on a scale of 0 to 8 （0=almost never, 8=almost always）, the intravaginal ejaculatory latency time （IVELT） was graded on a scale of 0 to 3 （0=longer than 5 minutes, 3 =shorter than 1 minute）. 28 men who remained dissatisfied with all treatment modalities scored their PE as 4 or greater and IVELT 2 or greater comprised in the study group, all of them took paroxetine 20 mg for 30 days and sildenafil 50mg 2-3 hours before intercourse p.r.n. PE was graded using the same scales 3 months after the initiation of the treatment. Results The mean initial PE index was 5.69±0.13 and that for IVELT was 2.81±0.21 for all participants. The mean final PE index was 1.77±0.22 （P〈0.01 ） and IVELT was 0.16±0.36 （P〈0.01）. From the result of the treatment, 26 of the 28 men reported improvement and 22 were significant. Conclusion Sildenafil combined with paroxetine can alleviate refractory PE.

关 键 词：早泄 西地那非 帕罗西汀 治疗 

分 类 号：R698[医药卫生—泌尿科学]