B型脑钠肽在鉴别老年患者支气管哮喘急性发作与心源性哮喘中的作用探讨  

Study on Plasma Brain Natriuretic Peptide for Distinguishing Asthma and Acute Cardiac Insufficiency in the Elderly

作　　者：黄少丹[1] 田利奇[1] 张永健[1] 陈飞鹏[1] 

机构地区：[1]广州医学院第二附属医院呼吸科,广东广州510260

出　　处：《医学临床研究》2006年第7期996-997,共2页Journal of Clinical Research

基　　金：广东省医学科研项目(A2001267)

摘　　要：【目的】探讨B型脑钠肽(BNP)在鉴别老年患者支气管哮喘急性发作与心源性哮喘中的作用。【方法】测定71例确诊为支气管哮喘的老年患者急性加重期和缓解期血浆BNP水平并与65例心源性哮喘患者进行比较,同时对比分析其动脉血氧分压(PaO2)、平均动脉压(MAP)、心率(HR)的关系。【结果】支气管哮喘患者急性加重期血浆BNP水平(109.98±13.74)ng/L显著低于心源性哮喘(1 125.63±302.54)ng/L(P<0.01)。在心源性哮喘控制后72 h的BNP浓度与哮喘急性发作期比较,差异亦有显著性(P<0.05)。【结论】BNP能较好地鉴别老年患者支气管哮喘急性发作与心源性哮喘,其过程简单方便,值得临床推广应用。[Objective]To construct a new possible method for distinguishing asthma and acute cardiac insufficiency in the elderly. [Methods]Peripheral blood brain natriuretic peptide（BNP）,PaO2 were measured in 71 patients with elderly asthma and 65 patients with acute cardiac insufficiency. Their MAP,HR recorded in acute exacerbation and relaxing period. [Results]The level of plasma NNP decreased obviously in asthma on acute exacerbation compared with that in acute cardiac insufficiency （ P 〈0.01 ）, and difference in relaxing period of the two groups was significant（ P 〈0.01）. When the level of plasma BNP was dropping, clinic symptoms improved in patients with acute cardiac insufficiency . [Conclusion]It is an effective method to measure peripheral blood BNP to distinguish asthma and acute cardiac insufficiency in the elderly .

关 键 词：哮喘/诊断 呼吸困难 阵发性/诊断 利钠肽 脑/血液 

分 类 号：R562.25[医药卫生—呼吸系统]