联合检测尿脱氧吡啶啉与骨源性碱性磷酸酶诊断骨质疏松症  

Combined determination of urinary deoxypyridinoline and bone alkaline phosphatase and its diagnostic value for osteoporosis

作　　者：陈新军[1] 霍维玲[2] 李香业[2] 王建强[2] 王继华[2] 王美 

机构地区：[1]徐州医学院第二附属医院检验科,江苏徐州221006 [2]徐州医学院第二附属医院骨科,江苏徐州221006 [3]清原县中医院检验科,辽宁清原113300

出　　处：《临床检验杂志》2006年第4期253-254,共2页Chinese Journal of Clinical Laboratory Science

摘　　要：目的探讨尿脱氧吡啶啉(DPD)排泄率及骨源性碱性磷酸酶(BAP)对骨质疏松症患者的诊断价值及两者的相关性。方法对73例骨质疏松症患者在其治疗前后联合测定尿DPD、Cr,血BAP、钙(Ca)、磷(P)、碱性磷酸酶(ALP)及跟骨骨密度(BMD),以50例健康人作对照。结果骨质疏松症患者BAP(U/L)比对照组(213±8.13比142±6.08),DPD/Cr排泄率(nmol/mmolCr)比对照组(6.11±2.14比3.24±1.62)均显著增高(P<0.01),且治疗前后差异有显著性(P<0.01)。两指标之间成正相关(r=0.52)。结论BAP、DPD/Cr测定结果灵敏,比BMD经济方便,可作为骨质疏松症患者诊断的指标。Objective To investigate the diagnostic value of excretion rate of deoxypyridinoline（DPD） in urine and bone-specific alkaline phosphatase（BAP） in serum for osteoporosis and the correlation between the 2 indexes. Methods The level of Ca2 ＋ ,P,alkaline phosphatase （ALP）, BAP in blood, DPD, Cr in urine and bone mineral density （BMD） of the first to the fourth lumbar vertebrae were measured in seventy-three patients with osteoporosis, then the results were compared to those from fifty healthy subjects. Results The level of BAP and excretion rate of DPD in patients increased evidently in comparison with the healthy subjects groups（ P 〈 0.01 ）, and there was a great difference between the results before and after treatment（ P 〈 0.01 ）. There was positive correlation between the levels of BAP and DPD/Cr. Conclusions The determination of BAP and DPD/Cr is sensitive, and more convenient and economical than BMD, so BAP and DPD may be useful as diagnostic indexes for osteoporosis.

关 键 词：尿脱氧吡啶啉 骨源性碱性磷酸酶 骨质疏松症 

分 类 号：R446.1[医药卫生—诊断学]