心肺复苏后犬脑组织一氧化氮浓度的变化及纳络酮的干预  

The Effects of Naloxone on Concentration of Nitric Oxide in Postresuscitation Dog from Cardiac Arrest

作　　者：许松青[1] 陈卓堃[2] 林珮仪[1] 

机构地区：[1]广州医学院第二附属医院急诊科,510260 [2]广州市第一人民医院急诊科

出　　处：《岭南急诊医学杂志》2006年第4期243-244,共2页Lingnan Journal of Emergency Medicine

基　　金：广东省卫生厅资助项目(编号:A2005066)

摘　　要：目的:探讨犬心肺复苏(CPR)后6h脑组织形态学和一氧化氮(NO)浓度的变化以及纳络酮对两者的影响。方法:18只健康杂种犬随机分成三组(n=6),空白组:不诱发室颤,6h后取脑组织;对照组:心跳骤停后予常规心肺复苏术;纳络酮组:心跳骤停后予常规心肺复苏术并使用纳络酮。对照组和纳络酮组于复苏后6h取脑组织行NO浓度测定以及形态学检查。结果:对照组脑组织NO的含量高于空白组和纳络酮组,均P<0.01。纳络酮组的病理损害低于对照组。结论:纳络酮可减轻心肺复苏后脑组织NO的生成,减轻神经元的再灌注损伤。Objective： To explore the effect of Nitric Oxide（NO） concentration and the pathological change of dog＇s cerebral tissue after 6 hours CPR, and their effect by naloxone. Methods： 18 healthy adult cross dogs separate three groups stochastically （n=6）. Blank group were not induced ventricular fibrillation, collected the cerebral tissues after 6 hours; control group actualized standard CPR after cardiac arrest; naloxone group actualized standard CPR and used naloxone after cardiac arrest. The control group and naloxone group were collected the cerebral tissues after 6 hours when they have been actualized CPR and detect there NO concentration and pathological change. Result： The concentration of NO in control group were higher than those blank group （P 〈 0.01） and naloxone group （P 〈 0.01）. Control group presented obvious pathological damage of nerve cell and the damage of naloxone group was lower than the control group. Conclusion： Naloxone can reduce the NO in cerebral tissue after cardiopulmonary resuscitation （CPR） and reduce the nerve cell＇s reperfusion injury.

关 键 词：心肺脑复苏 一氧化氮 纳络酮 犬 

分 类 号：R459.7[医药卫生—急诊医学]