硫氮酮对血压、血浆内皮素及血管紧张素Ⅱ水平的影响  

Effects of Diltiazem on Blood Pressure,Plasma Endothelin and Angiotensin II Levels

作　　者：曹悦鞍[1] 石湘芸[1] 吴新生[1] 刘桂芳[1] 赵云涛[1] 

机构地区：[1]中国人民解放军海军总医院干三科,北京100037

出　　处：《天津医药》1996年第12期711-714,共4页Tianjin Medical Journal

摘　　要：40例原发性高血压病患者分别口服常释型(A组,20例)和缓释型(B组,20例)硫氮草酮4周。A组服60mg3次/日,B组服90mg2次/日;总有效率分别为85.0％、90.0％,与治疗前比较均有明显的降压效果(P<0.01)。用放射免疫分析法测定A组治疗前后的血浆内皮素(ET)和血管紧张素Ⅱ(AⅡ)含量,服药前二者水平较对照组显著升高(P<0.01),与血压升高的程度均呈正相关;服药后二者水平均显著下降(P<0.01),但仍高于对照组(P<0.01)。ET和AⅡ的下降幅度也有明显的相关性(r=0.549 P<0.01)。提示ET和AⅡ在高血压发病中均起重要作用,硫酸草酮的降压作用可能与通过降低Ca^(2+)内流,拮抗ET和AⅡ的生物学效应有关。Diltiazem were given by common type(group A, 20 cases, 60mg 3times a day)and by slow-released type (group B, 20cases, 90mg 2times a day)in 40patients with essential hypertension for 4 weeks. The overall effectiveness rates were 85. 0% and 90. 0% respectively (P<0. 01). Plasma endothelin and angiotensin II concentrations were measured with radioimmunoassys in group A. Comparing with control group,both plasma endothelin and angiotensin II were elevated significantly before administration (P<0. 001) ,but were decreased markedly after therapy (P<0. 01). This study showed that the changes of blood pressure,plasma endothelin and angiotensin II all were positively in- terrelated. It is suggested that endothelin and angiotensin II may play an important role in the patho-genesis of essential hypertension. By blocking calcium-channel, antagonizing the biological effects of endothelin and angiotensin II diltiazem decreases blood pressure.

关 键 词：硫氮ZHOU酮 高血压 内皮素 血管紧张素II 

分 类 号：R544.105[医药卫生—心血管疾病]