溃疡性结肠炎与一氧化氮和氧自由基关系及丹参治疗作用研究  

Relationship between ulcerative colitis and the levels of nitric oxide and oxygen free radical in serum and intestine mucosal and the treatment of ulcerative colitis with Tanshinone

作　　者：刘建生[1] 田怡[1] 张晓红[1] 冯莉[1] 刘进[1] 付极[1] 吴云林[2] 袁耀宗[2] 

机构地区：[1]上海瑞金医院集团闵行医院消化科,上海201100 [2]上海交通大学医学院附属瑞金医院消化科

出　　处：《中国医师杂志》2006年第8期1040-1042,共3页Journal of Chinese Physician

基　　金：上海市科学技术委员会科研计划资助项目(044119751)

摘　　要：目的研究溃疡性结肠炎(UC)患者血、肠黏膜中一氧化氮(NO)和超氧化歧化酶(SOD)变化及丹参对其影响,并探讨丹参治疗UC疗效。方法UC患者79例随机分为治疗组(A组)40例,常规治疗组(B组)39例。A组常规治疗+丹参静脉给药,B组常规治疗。2组治疗前后测定血、肠黏膜中NO和SOD变化,并观察临床症状改善、肠镜检查的情况和住院天数进行比较。同时期选健康者20人(C组)作对照。结果UC时血、肠黏膜中NO增高、SOD减少明显与对照组比较差异有统计学意义(P<0.01)。UC治疗后A组血、肠黏膜中NO和SOD恢复常态与B组相比有统计学意义(P<0.01);且临床症状改善率、肠黏膜征象复常率和住院天数缩短也明显优异B组(P<0.01)。结论UC患者血、肠黏膜中NO和SOD异常,可能是UC发生和发展主要因素之一;丹参有效治疗UC与其拮抗NO、氧自由基机制有关。Objective To explore the changes of nitric oxide （NO） and superoxide dismutase （SOD） in the serum and intestine mucosal and the treatment of ulcerative colitis （UC） with Tanshinone. Methods Seventy-nine patients with UC were randomly divided into the treatment group （group A, n =40） and the routine treatment group （group B, n =39）. Patients in the group A were given Tanshionon and routine treatment. Patients in group B were given routine treatment. The levels of NO and SOD were measured in all patients before and after the treatment. The Clinical symptom, enteroscopy, and hospital day were compared in the patients of the two groups. Twenty normal healthy controls （ group C ） were involved in the study. Results The NO level in the serum and intestine mucosal was significantly increased and the SOD level was significantly decreased in the patients with UC compared with those of the controls （all P 〈0.01 ）. The levels of NO and SOD in the serum and intestine mucosal were recovered after the treatment in the patients of group A and were significantly different from those of group B （ P 〈0.01 ）. The clinical symptom, enteroscopy, and hospital day in patients of group A were superior to those of group B （ P 〈0.01 ）. Conclusion The abnormal levels of NO and SOD in the serum and intestine mucosal may play an important role in the development of UC. Tanshinone is effective in the treatment of UC by the antagonism of NO and SOD.

关 键 词：结肠炎 溃疡性 一氧化氮 活性氧 丹参/治疗应用 

分 类 号：R259[医药卫生—中西医结合]