醋酸纤维素聚合物栓塞实验性宽颈动脉瘤影像学研究  

Embolization of experimental wide-neck aneurysms with cellulose acetate polymer-the angiographic study

作　　者：吕明[1] 吴中学[1] 姜鹏[1] 姜除寒[1] 李佑祥[1] 张静波[1] 杨新健[1] 张友平[1] 尹可[1] 

机构地区：[1]北京市神经外科研究所 首都医科大学附属北京天坛医院,100050

出　　处：《中华神经外科杂志》2006年第7期416-419,共4页Chinese Journal of Neurosurgery

基　　金：北京市卫生局科研项目基金资助(2004-局-013)

摘　　要：目的观察非粘附性液体栓塞剂醋酸纤维素聚合物(CAP)栓塞实验性宽颈动脉瘤的影像学效果。方法家猪7只,将静脉袋端-侧吻合于颈总动脉建立侧方宽颈动脉瘤模型。动脉瘤制作后1-3d行CAP结合球囊再塑形技术栓塞。栓塞术后1个月行造影复查。结果7只动物共制作10个动脉瘤。对8个动脉瘤行栓塞,除在1个动脉瘤模型中微导管破裂导致载瘤动脉闭塞以外,余7个动脉瘤均获完全栓塞并保留载瘤动脉；栓塞术后1个月复查造影显示动脉瘤无再通,载瘤动脉保留率降至62．5%。结论CAP结合球囊再塑形技术能够实现完全栓塞宽颈动脉瘤并保留载瘤动脉的影像学效果。Objective To observe the angiographic effect of embolization of experimental wide-neck aneurysms with cellulose acetate polymer （CAP） -a kind of non-adhesive liquid embolic material. Methods The technique of end-to-side vein pouch anastomosis to artery was adopted to make lateral wide-neck aneurysms in seven swines. The aneurysms were embolized with CAP and remodeling technique, and were examined by angiography one month later. Results Ten aneurysms were made in seven swines. Eight aneurysms were embolized. In one aneurysm model the parent artery was occluded because of microcatheter fracture. The other seven aneurysms were all completely occluded with their parent arteries patent. Follow-up angiography one month later showed no aneurysm recanalization occurred and the patency rate of the parent arteries decreased to 62. 5%. Conclusions Complete embolization of wide-neck aneurysms with their parent arteries patent can be achieved with CAP and remodeling technique.

关 键 词：醋酸纤维素聚合物 实验性动脉瘤 栓塞 血管造影 

分 类 号：R651.12[医药卫生—外科学]