高胆固醇对Oddi括约肌舒缩性与[Ca^(2+)]i的影响  

Correlation Between Hypercholesterol and the Tension and [Ca^(2+)]i of SO in Rabbit

作　　者：杜滂[1] 魏经国[1] 马克军[1] 王亚蓉[1] 张孝勇[1] 南海燕[1] 

机构地区：[1]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《实用放射学杂志》2006年第7期769-772,共4页Journal of Practical Radiology

基　　金：国家自然科学基金资助项目(30470787)

摘　　要：目的探讨高胆固醇对Odd i括约肌张力及细胞内钙离子浓度的影响。方法新西兰兔16只随机分为2组,对照组8只,实验组8只,分别对对照组及实验组兔行Odd i括约肌测压、造影、胆管括约肌(SO)细胞中钙离子浓度测定。结果对照组兔血清胆固醇浓度<3 mmol/L,实验组兔血清胆固醇浓度约30 mmol/L左右;胆管造影显示实验组造影剂排空时间延迟,Odd i括约肌狭窄;Odd i括约肌近侧段基础压力测定,对照组和实验组分别为1.56 kPa和3.41 kPa(P<0.01),Odd i括约肌高压带(HPZ)压力分别为9.24 kPa和19.27 kPa(P<0.0.1);SO细胞中钙离子浓度测定显示实验组较对照组升高。结论高胆固醇血症可引起细胞内钙离子浓度升高及Odd i括约肌张力持续升高。Objective To study the effect of hypercholesterolemia on the tension and intracellular Ca^2＋ concentration of sphinter of Oddi （ SO ） . Methods 16 New Zealand rabbits were divided into two groups randomly . Both control group and test group had 8 rabbits. The pressure and intracellular Ca^2＋ of SO were measured , and cholangiopanceatography was performed in both control group and test group . Results In control group,the serum total cholesterol concentration was lower than 3retooL/L, while, in test group that was about 30 mmoL/L. The basic pressure of the proximal segment of SO was about 1.56 kPa in control group and 3.41 kPa in test group （ P 〈 0.01 ）. The basic pressure of the high pressure zone （HPZ） was about 9.24 kPa in control group and 19.27 kPa in test group （P 〈 0.01 ）. Cholangiopancreatography showed SO was in contraction the time of contrast agent emptied was dallied in test group. [ Ca^2＋ ] i and calcium oscillation amplitude and frequency were 36.4 ± 6.2, 3.61 ± 0.94, 6 ± 2 per minute separately in control group, while in test group, [Ca^2＋ ]i and calcium oscillation amplitude and frequency were 44.3 ± 2.05, 6.11 ± 3.1, 9 ± 2.1 per minute separately. Conclusion The disorder of cholesterol metabolism is an important cause of sphinter of Oddi dysfunction.

关 键 词：胆固醇 细胞内钙离子浓度 胆管括约肌 钙依赖性钾通道 

分 类 号：R322.45[医药卫生—人体解剖和组织胚胎学] R322.48[医药卫生—基础医学]