60例健康人脑水分子扩散加权成像正常表观扩散系数的定量研究  

The quantitative study on apparent diffusion coefficient value with diffusion-weighted MR imaging in 60 healthy people's brains

作　　者：汪延明[1] 田建明[2] 肖作平[3] 赵修义[4] 居小平[3] 

机构地区：[1]济南军区总医院放疗科,济南市250031 [2]第二军医大学长海医院放射科 [3]第二军医大学长海医院放疗科 [4]济南军区总医院,核医学科,济南市250031

出　　处：《中华老年医学杂志》2006年第7期510-513,共4页Chinese Journal of Geriatrics

摘　　要：目的对健康老年人30例(老年组)脑水分子扩散加权成像进行实验研究,并与健康非老年人30例(非老年组)进行对照,探讨年龄因素对健康人脑白质及灰质核团表观扩散系数(apparent diffusion coefficient,ADC)值的影响。方法对2组对象进行脑水分子扩散加权成像,并分别测量额叶和枕叶白质ADC值作为皮质下白质的代表,测量丘脑ADC值作为灰质的代表。结果老年组脑白质ADC平均值(ADCav)为(0．73±0．10)×10-3mm2/s、丘脑为(0．84±0．06)×10-3 mm2／s,非老年组分别为(0．70±0．07)×10-3mm2／s和(0．83±0．08)×10-3mm2／s,2组脑白质差异有统计学意义(P<0．05),丘脑间差异无统计学意义;同组白质和丘脑间差异有统计学意义(P< 0．001)。结论健康人随年龄增长,正常脑白质ADC值呈现微弱的增长趋势,尤其是老年人增长趋势更为明显;定量ADC值分析,对疾病的早期诊断及检测病变的发生、发展有重要的意义;临床研究中在对照组的选取上应注意年龄因素的影响,本研究所得数据可作为进一步研究正常参考值。Objective To evaluate the influence of age on apparent diffusion coefficient （ADC） value of white and grey matter in healthy elderly group and non-elderly group. Methods Sixty cases were divided into two groups： elderly group （age≥60 yr） and non-elderly group （age〈60 yr）. Diffusion-weighted imaging （DWI） was performed in 30 clinically healthy elderly brains and compared with healthy non-elderly brains ADC values of white matter of frontal lobe and occipital lobe were measured as subcortical white matter, while ADC values of thalamus were measured as the grey matter. Results The average values of ADC （ADCav）in white matter were （0.73±0.10）×1^0-3 mm^2/s in elderly group and （0.70±0.07）× 10^-3 mm^/s in non-elderly group. Those values in cerebral ganglion were （0.84±0.06）×10^-3 mm^2/s and （0.83±0.08）×10^-3 mm^2/s respectively. Significant difference was present in white matter ADCav between two groups （P〈0.05 ） , so were white matter and cerebral ganglion in the same groups（all P〈0.001）. Conclusions ADC value of normal white matter presents tenuous increasing with aging in healthy people, especially in elderly people. Quantitative analysis of ADC value has important implications in early diagnosis, occurrence and development of diseases. In clinical research, age factor should be paid attention to while selecting a control group. Data from this study can be taken into account as normal reference value for further investigation.

关 键 词：磁共振成像 弥散 丘脑 

分 类 号：R445.2[医药卫生—影像医学与核医学]