三七三醇皂甙对动物血小板功能及血栓形成的影响  

Effects of Panaxatriol Saponins Isolated from Sanchi(Panax pseudo-ginseng var.notoginseng)on Animal Platelet Function and Thrombosis

作　　者：苏雅[1] 赵益桂[1] 张宗鹏 岳南 

机构地区：[1]国家医药管理局天津药物研究院,300193

出　　处：《中草药》1996年第11期666-669,共4页Chinese Traditional and Herbal Drugs

摘　　要：三七三醇皂甙（PTS）在体外（1～4mg／ml）和体内十二指肠给药（75～300mg／kg）都明显抑制由ADP、胶原、花生四烯酸（AA）诱导的大鼠及家兔血小板聚集，同时亦抑制胶原诱导大鼠血小板TXA2释放，而对大鼠胸主动脉壁PGI2生成无明显影响。PTS（50～200mg／kg）明显抑制大鼠实验性血栓形成，剂量与效应相关。提示：PTS抗血栓作用与其抑制血小板聚集和TXA2释放有关。Panaxatriol saponin (PTS), isolated from Panax pseudo-ginseng var. notoginseng, 1~ 4mg/ml inhibited rabbit platelet aggregation induced by ADP,collagen and arachidonic acid respectively in vitro. In rat,PTS 75 ~300mg/kg intraduodenally inhibited dose-dependently platelet aggregation induced by these inducers, andalso inhibited platelet thrombonane A2 release induced by collagen,but did not affect the formation of aorticwall PGI2,PTS 50~200mg/kg significantly inhibited experimental thrombosis in rats. These results showed that the anti-thrombosis action of PTS may be due to its inhibitory action on platelet aggregation and TXA2re lease

关 键 词：三七三醇皂甙 血小板 血栓形成 中药药理学 

分 类 号：R285.5[医药卫生—中药学]