流感病毒H_3N_2亚型HA_1基因变异分析  

Sequencing on Influenza A H_3N_2 Subtypes and Study on Their HA_1 Gene Variation

作　　者：黄平[1] 蔡初的[1] 郝瑞丰[1] 陈伟师[1] 沈桂章[1] 谭丽霞[1] 倪汉忠[1] 黄介枚[1] 

机构地区：[1]广东省卫生防疫站

出　　处：《中国人兽共患病杂志》1996年第6期3-7,共5页Chinese Journal of Zoonoses

基　　金：卫生部青年科学研究基金;世界卫生组织项目研究基金

摘　　要：１９９４年流感病毒Ｈ３Ｎ２亚型ＨＡ１基因核苷酸序列分析结果显示，经过２６年进化，共有１１４个核苷酸置换，引起５１个氨基酸变异，变异比例为１５．５％。自１９６８年＂香港流感＂引起人类暴发流行以来，ＨＡ１基因核苷酸置换率４～６个／每年，氨基酸变异２～３个／每年，核苷酸和氨基酸变异速度减慢。１９９４年三株病毒中，广东地区毒株比仙台地区和河北地区毒株多变异２～３个氨基酸；这从分子流行病学角度提示，广东地区流行毒株在目前流感病毒Ｈ３Ｎ２亚型的变异和流行中可能具有重要作用。It is revealed in sequencing of influenza A H3N2 strains in 1994 that when compared with H3N2 that first appeared in 1968,there were 114 nucleotieds substitutions and 51 amino acid variations with 15. 5% of variation rate, There were annually 4～6 nucleotide substitutions and 2～3 amino acid variations in HA1 gene since 1968. A G and CT were the main way of substitution, which was 73. 2% in all. Nucleotide substitution and amino acid variation has been slowed down gradually since the 1980's. Among three strains in 1994, there were 2～3 amino acid more variation in A/Guangdong/28/94 than in A/Sendai/c384/94 and A/Hebei/41/94 in HA1.

关 键 词：流感病毒 血凝素基因 序列分析 变异 

分 类 号：R373.13[医药卫生—病原生物学]