血管内皮细胞生长因子促进激素性股骨头坏死修复  

Effect on avascular necrosis of the femoral head with vascular endothelial growth factor

作　　者：胡志明[1] 王海彬[2] 李祖国[1] 肖承江[3] 马骊[1] 王小宁[1] 

机构地区：[1]南方医科大学分子免疫学研究所,广州510515 [2]广州中医药大学第一附属医院骨科,广州510450 [3]广东省第二人民医院介入科,广州510317

出　　处：《中国矫形外科杂志》2006年第15期1179-1181,共3页Orthopedic Journal of China

基　　金：广州市科技计划(No.2003Z2-E0171);广东省科技攻关计划(No.2004B31201010);军队医药卫生科研基金(No.04LX028)资助

摘　　要：[目的]探讨应用血管内皮细胞生长因子治疗激素性股骨头坏死的方法。[方法]新西兰兔30只,22只兔耳缘静脉注射马血清,臀肌注射醋酸泼尼松龙,制造激素性股骨头坏死动物模型。动物随机分为3组:A组:VEGF治疗组,B组:对照组,C组:正常对照组。治疗组骨穿刺针行经皮注射血管内皮细胞生长因子脂质体至股骨头。于治疗后5周,采用影像学方法观察股骨头结构变化,病理组织学观察股骨头骨组织、骨髓造血组织及血管的变化。[结果]VEGF治疗组,X线及CT检查显示:模型股骨头结构变清晰,骨质破坏明显修复;HE染色结果:VEGF治疗组可见软骨细胞修复性增生,骨髓腔造血组织出现增生,栓塞的血管旁边出现新生的血管。[结论]VEGF治疗股骨头坏死能促进新血管生成及骨修复。[ Objective ] To explore a new method for the therapy of avaseular necrosis of the femoral head with vascular endothelial growth factor （VEGF） . [ Method] Thirty New Zealand white rabbits were chosen as experimental animals and avascularnecrosis of the femoral head model of 22 rabbits were established. Animals were egnally divided into three groups ： VEGF group, natural repair group, normal group. The medicament was injected to the femoral head by percutaneous injection in group A and normal saline in group B. The repairing process of bone necrosis of femoral head were studied. [Result] Compared to the untreated model group （group C）, the femoral head of VEGF groups showed significant new vessel formation, number of empty bone lacunae decreased and hematopoietic tissue improving in marrow cavity. X-ray film and CT revealed evident that veGF could enhance repairing of the femoral head. [Conclusion] Pereutaneous injection of VEGF to the necro femoral head could significantly enhance bone tissue angiogenesis and ameliorated repair of osteonecrosis, thus providing a potential method for the treatment of the femoral head necrosis.

关 键 词：血管内皮细胞生长因子 股骨头坏死 治疗 

分 类 号：R681.8[医药卫生—骨科学]